Name: Exisulind
Brand: TargetMol
SKU: T24051
Price: 283 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 283

现货

5 mg

¥ 663

现货

10 mg

¥ 987

现货

25 mg

¥ 1,990

现货

50 mg

¥ 2,970

现货

100 mg

¥ 4,280

现货

500 mg

¥ 8,850

现货

1 mL x 10 mM (in DMSO)

¥ 547

现货

产品介绍

生物活性

产品描述	Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
体内活性	经外用NO-Exisulind处理显著减少了SKH-1无毛鼠UVB诱导的肿瘤。与仅接受车载剂处理和UVB照射的阳性对照组相比，肿瘤数量/每只鼠、肿瘤体积/每只鼠均显著下降（P < 0.05）。NO-Exisulind处理的动物展现出增殖标记物，如PCNA和cyclin D1的表达降低，同时显示出促凋亡蛋白Bax的表达增加以及抗凋亡蛋白Bcl2的表达降低，并伴随肿瘤中TUNEL阳性细胞数量的增加。NO-Exisulind处理的肿瘤具有较低的侵袭性，并且从良性向恶性癌症的进展效率降低[1]。
别名	Sulindac sulfone, CP248

化学信息

分子量	372.41
分子式	C₂₀H₁₇FO₄S
CAS No.	59973-80-7
Smiles	CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)(=O)=O
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (147.69 mM), Sonication is recommended.

溶液配制表

DMSO

体内实验配液计算器