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ML348

Name: ML348
Brand: TargetMol
SKU: T3439
Price: 258 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: GNF-Pf-1127

货号 T3439Cas号 899713-86-1 一键复制产品信息纯度: 99.88%

很棒

ML348 (GNF-Pf-1127) 是一个选择性的、可逆的酰基蛋白硫酯酶 1 (APT1)/溶血磷脂酶 1 (LYPLA1) 抑制剂，IC50=210 nM。

ML348

一键复制产品信息

很棒

纯度: 99.88%

货号 T3439Cas号 899713-86-1

别名 GNF-Pf-1127

ML348 (GNF-Pf-1127) 是一个选择性的、可逆的酰基蛋白硫酯酶 1 (APT1)/溶血磷脂酶 1 (LYPLA1) 抑制剂，IC50=210 nM。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 258	现货
2 mg	¥ 378	现货
5 mg	¥ 647	现货
10 mg	¥ 955	现货
25 mg	¥ 1,980	现货
50 mg	¥ 2,950	现货
100 mg	¥ 4,350	现货
200 mg	¥ 6,150	现货
500 mg	¥ 9,130	待询

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.87%

颜色: 白色

资源下载: COA LCMS HNMR 产品操作手册

产品介绍

ML348 AI Summary

ML348 demonstrates a variety of biological activities and potencies across different assays. It shows moderate inhibition of Plasmodium falciparum 3D7 (drug-susceptible) with an EC50 value of 4040.0 nM but has no significant effect on the drug-resistant W2 strain. It exhibits substantial cytotoxicity against the human hepatocellular carcinoma cell line Huh7 with a CC50 value greater than 100000.0 nM and does not induce or inhibit activity in the Inhibition Frequency Index (IFI) assay. The compound acts as a delayed death inhibitor of the malarial parasite plastid with a potency of 1651.1 nM, and enhances SMN2 splice variant expression with a potency of 14125.4 nM. It inhibits multiple targets including Cruzain (39810.7 nM), ALDH1A1 (39810.7 nM), ELG1-dependent DNA repair in HEK293T cells (29092.9 nM), and human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 23109.3 nM (absence of CPT) and 20596.2 nM (presence of CPT). It exhibits lower potencies as an agonist of gsp (50118.7 nM) and inhibitor of the HIV-1 protein Vpr (63095.7 nM). Notably, 585472 inhibits APT1 with a Ki of 300.0 nM but shows no significant inhibition of APT2 (Ki > 10000.0 nM). With regards to antiviral activities, ML348 shows inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a mild inhibition of -1.38% at 10 µM after 48 hours. It also exhibits SARS-CoV-2 3CL-Pro protease inhibition, achieving 7.63% and 13.55% inhibition at 20 µM. Additionally, it demonstrates varying levels of inhibition against SARS-CoV-2 cytotoxicity in VERO-6 cells. In enzymatic assays, the compound shows inhibitory action on human HDAC6, with inhibition percentages of 18.28% for a commercial peptide substrate and 6.92% for a custom peptide substrate. ML348 presents a broad spectrum of biological activities with potential implications in antimalarial, antiviral, and cancer therapeutic research..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
靶点活性	LYPLA1:210 nM
别名	GNF-Pf-1127

化学信息

分子量	415.79
分子式	C₁₈H₁₇ClF₃N₃O₃
CAS No.	899713-86-1
Smiles	FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
密度	1.422 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 83.33 mg/mL (200.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.94 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4051 mL	12.0253 mL	24.0506 mL	120.2530 mL
5 mM	0.4810 mL	2.4051 mL	4.8101 mL	24.0506 mL
10 mM	0.2405 mL	1.2025 mL	2.4051 mL	12.0253 mL
20 mM	0.1203 mL	0.6013 mL	1.2025 mL	6.0127 mL
50 mM	0.0481 mL	0.2405 mL	0.4810 mL	2.4051 mL
100 mM	0.0241 mL	0.1203 mL	0.2405 mL	1.2025 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。