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HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and inhibits cell proliferation. Additionally, HDAC-IN-42 induces apoptosis and causes cell cycle arrest specifically at the G2/M phase [1].
HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and inhibits cell proliferation. Additionally, HDAC-IN-42 induces apoptosis and causes cell cycle arrest specifically at the G2/M phase [1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 14,900 | 6-8周 | |
50 mg | ¥ 19,420 | 6-8周 | |
100 mg | ¥ 24,625 | 6-8周 |
产品描述 | HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and inhibits cell proliferation. Additionally, HDAC-IN-42 induces apoptosis and causes cell cycle arrest specifically at the G2/M phase [1]. |
靶点活性 | HDAC1:0.19 μM, HDAC6:4.98 μM |
体外活性 | HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C 50 s of 9.56, 13.32, 10.46, 6.91 μM for MCF-7, HCT-116, HepG2, Hela cells, respectively [1]. HDAC-IN-42 (1, 5, 10 μM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells [1]. HDAC-IN-42 (1, 5, 10 μM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase [1]. |
分子量 | 381.34 |
分子式 | C20H15NO7 |
CAS No. | 2454024-18-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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