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NLRP3-IN-9

Name: NLRP3-IN-9
Brand: TargetMol
SKU: T28178
Price: 328 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: INF-4E, INF4E, INF 4E

货号 T28178Cas号 88039-46-7 一键复制产品信息纯度: 99.64%

很棒

NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。

NLRP3-IN-9

一键复制产品信息

很棒

纯度: 99.64%

货号 T28178Cas号 88039-46-7

别名 INF-4E, INF4E, INF 4E

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 328	现货
5 mg	¥ 828	现货
10 mg	¥ 1,320	现货
25 mg	¥ 2,650	现货
50 mg	¥ 4,290	现货
100 mg	¥ 5,970	现货
200 mg	¥ 8,220	现货
1 mL x 10 mM (in DMSO)	¥ 767	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.64%

颜色: 无色透明

性状: Liquid

资源下载: COA HNMR LCMS GC产品操作手册

产品介绍

NLRP3-IN-9 AI Summary

NLRP3-IN-9 demonstrates broad-spectrum antimicrobial activity against a variety of bacteria and fungi, including Staphylococcus aureus, Corynebacterium diphtheriae, Klebsiella pneumoniae, Escherichia coli, Aspergillus niger, and Candida albicans, with the lowest minimum inhibitory concentration (MIC) of 13.0 ug/mL observed against Candida albicans. It also exhibits significant antipyroptotic effects, inhibiting ATP-induced and nigericin-induced pyroptosis in human THP1 cells with an inhibition rate of 75.1% at 10 uM and an EC50 of 158.49 nM, respectively. Additionally, NLRP3-IN-9 demonstrates reactivity with GSH and cysteamine, with second-order reaction rate constants of 0.866 /M/s and 0.824 /M/s. The compound inhibits NLRP3-ATPase activity by 51.8% at 10 uM and recombinant human NLRP3 ATPase activity by 72.0% at 100 uM, and it inhibits caspase 1 with a Ki value of 9600.0 nM and a Kinact value of 3.2 /s. Binding affinity to human serum albumin is 65.0% after 5 minutes. The TC50 for cytotoxicity against human HK2 cells is 67.0 uM after 72 hours, and against human THP1 cells, it is 65.0 uM after 72 hours. Additionally, in PMA-differentiated and LPS-primed human THP1 cells, it reduces ATP-induced pyroptosis by 80.9% at 10 uM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
别名	INF-4E, INF4E, INF 4E

化学信息

分子量	240.68
分子式	C₁₂H₁₃ClO₃
CAS No.	88039-46-7
Smiles	CCOC(=O)C(=C)C(O)c1ccccc1Cl
密度	1.222 g/cm3 (Predicted)

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (249.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.31 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1549 mL	20.7745 mL	41.5489 mL	207.7447 mL
5 mM	0.8310 mL	4.1549 mL	8.3098 mL	41.5489 mL
10 mM	0.4155 mL	2.0774 mL	4.1549 mL	20.7745 mL
20 mM	0.2077 mL	1.0387 mL	2.0774 mL	10.3872 mL
50 mM	0.0831 mL	0.4155 mL	0.8310 mL	4.1549 mL
100 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0774 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。