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Alogliptin

Name: Alogliptin
Brand: TargetMol
SKU: T6192
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.63%

货号 T6192Cas号 850649-61-5

别名 阿洛利停, 阿格列汀, SYR-322

Alogliptin (SYR-322) 是一种具有选择性口服活性的DPP-4的抑制剂，IC50值小于 10 nM，比对 DPP-8 和 DPP-9 的抑制性高 10000 倍以上，可研究 2 型糖尿病。

Alogliptin

一键复制产品信息

很棒

纯度: 99.63%

货号 T6192 别名 阿洛利停, 阿格列汀, SYR-322Cas号 850649-61-5

Alogliptin (SYR-322) 是一种具有选择性口服活性的DPP-4的抑制剂，IC50值小于 10 nM，比对 DPP-8 和 DPP-9 的抑制性高 10000 倍以上，可研究 2 型糖尿病。

规格	价格	库存	数量
100 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

Alogliptin AI Summary

Alogliptin exhibits potent inhibition of human Dipeptidyl Peptidase-4 (DPP4), with reported IC50 values consistently below 10 nM in various assays, including 3.4 nM, 4.0 nM, and 7.0 nM. This high potency against DPP4 highlights its potential as a therapeutic agent for modulating DPP4-related pathways, potentially for managing diabetes. The compound also demonstrates low or no significant inhibitory effects on other proteins such as DPP8, DPP9, and FAP, with IC50 values exceeding 25,000 nM, indicating a high selectivity for DPP4. Additionally, in vivo studies in mice and rats show that Alogliptin can significantly reduce blood glucose levels, suggesting its beneficial effects in diabetes treatment. The compound also presents a moderate half-life and bioavailability in human and animal models, indicating practical pharmacokinetic properties. Furthermore, limited activity against CYP enzymes and minimal cardiac side effects support its potential for safe use in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
靶点活性	DPP4:<10 nM
别名	阿洛利停, 阿格列汀, SYR-322

化学信息

分子量	339.39
分子式	C₁₈H₂₁N₅O₂
CAS No.	850649-61-5
Smiles	Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O
密度	1.342 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 68 mg/mL (200.36 mM), Sonication is recommended.

H2O: 2 mg/mL (5.89 mM), Sonication is recommended.

Ethanol: 60 mg/mL (176.79 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9465 mL	14.7323 mL	29.4646 mL	147.3231 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL	29.4646 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2946 mL	1.4732 mL	2.9465 mL	14.7323 mL
20 mM	0.1473 mL	0.7366 mL	1.4732 mL	7.3662 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	2.9465 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4732 mL