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Djenkolic Acid

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纯度: 98.77%

货号 T22311Cas号 498-59-9

别名 S,S'-Methylenebiscysteine, jengkolic acid, Djenkolate, 3,3'-(亞甲二硫)雙丙胺酸

Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。

Djenkolic Acid

Djenkolic Acid

一键复制产品信息
Rating icon 很棒

纯度: 98.77%

货号 T22311 别名 S,S'-Methylenebiscysteine, jengkolic acid, Djenkolate, 3,3'-(亞甲二硫)雙丙胺酸Cas号 498-59-9

Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。

规格价格库存数量
25 mg
¥ 117
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50 mg
¥ 150
现货
100 mg
¥ 196
现货
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产品介绍


Djenkolic Acid AI Summary
Djenkolic Acid exhibits strong growth inhibition activity against a wide range of human tumor cell lines, as evidenced by the NCI human tumor cell line growth inhibition assay. It shows significant potency in inhibiting the growth of various cancer cell lines, including renal, non-small cell lung, leukemia, ovarian, melanoma, central nervous system, colon, breast, and small cell lung cancer cell lines. The compound has demonstrated GI50 values ranging from 36,545.11 nM to 224,905.46 nM, indicating varying levels of effectiveness across different cell lines. In addition to its anti-cancer properties, Djenkolic Acid significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 μM, with inhibition levels of 92.41% and 96.92%, respectively. These findings suggest that Djenkolic Acid exhibits promising bioactivity as a potential anti-cancer agent and may also strongly interact with specific transporters..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Djenkolic Acid (S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans(Archidendron pauciflorum), which is native to Southeast Asia. It is an uncommon but important cause of acute kidney injury in human.
别名S,S'-Methylenebiscysteine, jengkolic acid, Djenkolate, 3,3'-(亞甲二硫)雙丙胺酸
化学信息
分子量254.33
分子式C7H14N2O4S2
CAS No.498-59-9
SmilesN[C@@H](CSCSC[C@H](N)C(O)=O)C(O)=O
密度1.4799 g/cm3 (Estimated)
颜色White
物理性状solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
5%TFA: 3 mg/mL (11.8 mM), Sonication is recommended.
DMSO: 0.1 mg/mL (0.39 mM), Sonication is recommended.

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg,每只动物体重20g,给药体积100 μLTargetMol | Animal experiments 一共给药动物10只,您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O, 那么您的工作液浓度为2mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween80, 混匀澄清,再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如: DMSOPEG300 / PEG400Tween 80SBE-β-CD玉米油 等, 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

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