购物车

您的购物车当前为空

Famciclovir

Name: Famciclovir
Brand: TargetMol
SKU: T1646
Price: 228 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.99%

货号 T1646Cas号 104227-87-4

别名 泛昔洛韦, BRL 42810

Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

Famciclovir

一键复制产品信息

很棒

纯度: 99.99%

货号 T1646 别名 泛昔洛韦, BRL 42810Cas号 104227-87-4

Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。

规格	价格	库存
25 mg	¥ 289	现货
50 mg	¥ 413	现货
100 mg	¥ 690	现货
200 mg	¥ 1,090	现货
500 mg	¥ 2,120	现货
1 mL x 10 mM (in DMSO)	¥ 228	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.99%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Famciclovir AI Summary

Famciclovir exhibits a broad spectrum of bioactivities across various in vitro and in vivo studies. It demonstrates significant antiviral activity against herpes simplex virus type 1 (HSV-1) with an EC50 value greater than 100,000.0 nM and shows cytotoxicity in Vero cells with a CC50 over 500,000.0 nM. Additionally, it has been observed to exhibit antiviral activity against viruses such as BK polyomavirus, woodchuck hepatitis virus, and SARS-CoV-2, although its efficacy against SARS-CoV-2 appears relatively low with inhibition rates and EC50 values indicating moderate potency. In pharmacokinetic studies, Famciclovir shows high oral bioavailability at 77.0% in humans, moderate oral clearance, and a relatively short half-life, accompanied by high systemic exposure and quick absorption. It demonstrates significant urinary recovery of penciclovir in both mice (48.0%) and rats (40.0%) over a 48-hour period post-administration. The compound also exhibits inhibitory activity against several biological targets including HSD17B4, JMJD2E, Cruzain, ALDH1A1, HPGD, and the Relaxin Receptor RXFP1, and shows potency in inhibiting the proliferation of Plasmodium falciparum strains. It inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected cells significantly, with inhibition percentages of 68.22% and 68.05%, respectively. However, Famciclovir has been associated with certain levels of hepatotoxicity indicated by the increase in liver enzymes such as ALT, AST, and alkaline phosphatase. The HepSE score for bilirubinemia and other liver function abnormalities suggests potential liver injury risks. Additional bioassays reveal varying effects on other biomarkers, indicating a notable impact on liver, kidney, blood, and metabolic functions. Overall, Famciclovir exhibits a complex profile with significant antiviral and antiprotozoal activities, moderate potency in inhibition assays, and notable pharmacokinetic properties, combined with a potential risk for liver toxicity. Further investigation and careful assessment are warranted to fully understand its therapeutic potential and safety profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Famciclovir (BRL 42810) is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and DNA Polymerase Inhibitor.
别名	泛昔洛韦, BRL 42810

化学信息

分子量	321.33
分子式	C₁₄H₁₉N₅O₄
CAS No.	104227-87-4
Smiles	CC(=O)OCC(CCN1C=NC2=C1N=C(N)N=C2)COC(C)=O
密度	1.40 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

Ethanol: 45 mg/mL (140.04 mM), Sonication is recommended.

DMSO: 45 mg/mL (140.04 mM), Sonication is recommended.

H2O: 59 mg/mL (183.61 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.22 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1121 mL	15.5603 mL	31.1207 mL	155.6033 mL
5 mM	0.6224 mL	3.1121 mL	6.2241 mL	31.1207 mL
10 mM	0.3112 mL	1.5560 mL	3.1121 mL	15.5603 mL
20 mM	0.1556 mL	0.7780 mL	1.5560 mL	7.7802 mL
50 mM	0.0622 mL	0.3112 mL	0.6224 mL	3.1121 mL
100 mM	0.0311 mL	0.1556 mL	0.3112 mL	1.5560 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Famciclovir

Famciclovir

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Famciclovir

Famciclovir

Famciclovir 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词