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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Famciclovir

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纯度: 99.99%

货号 T1646Cas号 104227-87-4

别名 泛昔洛韦, BRL 42810

Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。

Famciclovir
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Famciclovir

一键复制产品信息
Rating icon 很棒

纯度: 99.99%

货号 T1646 别名 泛昔洛韦, BRL 42810Cas号 104227-87-4

Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。

规格价格库存数量
25 mg
¥ 289
现货
50 mg
¥ 413
现货
100 mg
¥ 690
现货
200 mg
¥ 1,090
现货
500 mg
¥ 2,120
现货
1 mL x 10 mM (in DMSO)
¥ 228
现货
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产品介绍

Famciclovir AI Summary
Famciclovir exhibits a broad spectrum of bioactivities across various in vitro and in vivo studies. It demonstrates significant antiviral activity against herpes simplex virus type 1 (HSV-1) with an EC50 value greater than 100,000.0 nM and shows cytotoxicity in Vero cells with a CC50 over 500,000.0 nM. Additionally, it has been observed to exhibit antiviral activity against viruses such as BK polyomavirus, woodchuck hepatitis virus, and SARS-CoV-2, although its efficacy against SARS-CoV-2 appears relatively low with inhibition rates and EC50 values indicating moderate potency. In pharmacokinetic studies, Famciclovir shows high oral bioavailability at 77.0% in humans, moderate oral clearance, and a relatively short half-life, accompanied by high systemic exposure and quick absorption. It demonstrates significant urinary recovery of penciclovir in both mice (48.0%) and rats (40.0%) over a 48-hour period post-administration. The compound also exhibits inhibitory activity against several biological targets including HSD17B4, JMJD2E, Cruzain, ALDH1A1, HPGD, and the Relaxin Receptor RXFP1, and shows potency in inhibiting the proliferation of Plasmodium falciparum strains. It inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected cells significantly, with inhibition percentages of 68.22% and 68.05%, respectively. However, Famciclovir has been associated with certain levels of hepatotoxicity indicated by the increase in liver enzymes such as ALT, AST, and alkaline phosphatase. The HepSE score for bilirubinemia and other liver function abnormalities suggests potential liver injury risks. Additional bioassays reveal varying effects on other biomarkers, indicating a notable impact on liver, kidney, blood, and metabolic functions. Overall, Famciclovir exhibits a complex profile with significant antiviral and antiprotozoal activities, moderate potency in inhibition assays, and notable pharmacokinetic properties, combined with a potential risk for liver toxicity. Further investigation and careful assessment are warranted to fully understand its therapeutic potential and safety profile..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Famciclovir (BRL 42810) is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and DNA Polymerase Inhibitor.
别名泛昔洛韦, BRL 42810
化学信息
分子量321.33
分子式C14H19N5O4
CAS No.104227-87-4
SmilesCC(=O)OCC(CCN1C=NC2=C1N=C(N)N=C2)COC(C)=O
密度1.40 g/cm3 (Predicted)
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: 45 mg/mL (140.04 mM), Sonication is recommended.
DMSO: 45 mg/mL (140.04 mM), Sonication is recommended.
H2O: 59 mg/mL (183.61 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.22 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM3.1121 mL15.5603 mL31.1207 mL155.6033 mL
5 mM0.6224 mL3.1121 mL6.2241 mL31.1207 mL
10 mM0.3112 mL1.5560 mL3.1121 mL15.5603 mL
20 mM0.1556 mL0.7780 mL1.5560 mL7.7802 mL
50 mM0.0622 mL0.3112 mL0.6224 mL3.1121 mL
100 mM0.0311 mL0.1556 mL0.3112 mL1.5560 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

RNASynthesisRNA SynthesispenciclovirnucleosidemiceInhibitorinhibitinfectionHSVherpesvirusHerpes simplex virusHepatitis B virusHBVguanine analogueFamciclovirDNASynthesisDNA SynthesisDNA polymeraseBRL-42810BRL42810BRL 42359antiviral
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