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Miglustat

Name: Miglustat
Brand: TargetMol
SKU: T12039
Price: 297 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T12039Cas号 72599-27-0

别名 美格鲁特, OGT918, N-丙基脱氧野尻霉素, N-Butyldeoxynojirimycin, NB-DNJ

Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂，可用于I 型戈谢病。

Miglustat

一键复制产品信息

很棒

纯度: 99.92%

货号 T12039 别名 美格鲁特, OGT918, N-丙基脱氧野尻霉素, N-Butyldeoxynojirimycin, NB-DNJCas号 72599-27-0

Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂，可用于I 型戈谢病。

规格	价格	库存
1 mg	¥ 297	现货
5 mg	¥ 728	现货
10 mg	¥ 1,130	现货
25 mg	¥ 1,890	现货
50 mg	¥ 2,960	现货
100 mg	¥ 4,370	现货
1 mL x 10 mM (in DMSO)	¥ 786	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.92%

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COA HNMR LCMS 产品操作手册

产品介绍

Miglustat AI Summary

Miglustat exhibits a broad range of bioactivities, characterized by its inhibitory action against various glycosidases and enzymes involved in carbohydrate metabolism and glucosylceramide synthesis. Specifically, it inhibits alpha-glucosidases such as those found in rat intestinal brush border membranes, with notable IC50 values for maltase (2100 nM), sucrase (58000 nM), and isomaltase (2700 nM). It also inhibits lysosomal alpha-glucosidase, Golgi alpha-mannosidase II, and other related enzymes in rat liver, with competitive inhibition noted for endoplasmic reticulum alpha-glucosidase II and Golgi alpha-mannosidase II. In mice, Miglustat influences glycosphingolipid levels and demonstrates an inhibitory effect on glucosylceramide synthase (IC50 = 50000 nM) and glucosylceramidase with an IC50 of 140 nM. It shows varying inhibitory effects on maltase, lactase, and sucrase, and has shown potential antiviral activities, including inhibition of HIV-1 induced cytopathogenicity in MT-4 and MOLT-4 cells, and activity against SARS-CoV-2. In human cell studies, Miglustat inhibits beta-glucocerebrosidase and activates beta-glucocerebrosidase mutants, suggesting potential therapeutic implications for Gaucher disease. The compound shows limited Hepatic side effects, with a Drug-Induced Liver Injury (DILI) severity class of 0.0, indicating no significant concerns for liver toxicity in the tested settings. Additionally, it has shown stability in recombinant human lysosomal alpha-glucosidase, which is beneficial for enzyme replacement therapies. The compound demonstrates moderate antiviral activities against Dengue virus and Bovine viral diarrhea virus with an EC50 of 100000 nM for both, and has also shown antifungal activity and anti-inflammatory effects in human cells. Despite these bioactivities, Miglustat exhibits no significant inhibition or binding affinity towards some cellular components and receptors, suggesting that its inhibitory actions are selective and context-dependent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Miglustat (NB-DNJ) is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
别名	美格鲁特, OGT918, N-丙基脱氧野尻霉素, N-Butyldeoxynojirimycin, NB-DNJ

化学信息

分子量	219.28
分子式	C₁₀H₂₁NO₄
CAS No.	72599-27-0
Smiles	CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O
密度	1.234 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 130 mg/mL (592.85 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5604 mL	22.8019 mL	45.6038 mL	228.0190 mL
5 mM	0.9121 mL	4.5604 mL	9.1208 mL	45.6038 mL
10 mM	0.4560 mL	2.2802 mL	4.5604 mL	22.8019 mL
20 mM	0.2280 mL	1.1401 mL	2.2802 mL	11.4009 mL
50 mM	0.0912 mL	0.4560 mL	0.9121 mL	4.5604 mL
100 mM	0.0456 mL	0.2280 mL	0.4560 mL	2.2802 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

type I gaucher disease oral OGT-918 OGT 918 Miglustat Inhibitor inhibit ceramide glucosyltransferase

Miglustat

Miglustat

Miglustat 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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