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B7-H4 Protein, Human, Recombinant (hFc), Biotinylated

产品编号 TMPY-05280

别名: B7S1, B7X, VCTN1, B7h.5, V-set domain containing T cell activation inhibitor 1, PRO1291, B7H4, B7-H4

B7-H4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is Q7Z7D3-1.

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B7-H4 Protein, Human, Recombinant (hFc), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	B7-H4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is Q7Z7D3-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q7Z7D3-1
别名	B7S1, B7X, VCTN1, B7h.5, V-set domain containing T cell activation inhibitor 1, PRO1291, B7H4, B7-H4
蛋白构建	The Human VTCN1 (Q7Z7D3-1) (Phe29-Ala258) was expressed, fused with the Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	52.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Zang X,et al.(2003) B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A. 100(18): 10388-92. 2. Suh WK,et al.(2006) Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 26(17): 6403-11. 3. Zang X,et al.(2007) B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A. 104(49):19458-63.

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Keywords

B7-H4 Protein, Human, Recombinant (hFc), Biotinylated B7S1 B7X VCTN1 B7h.5 V-set domain containing T cell activation inhibitor 1 VCTN-1 PRO1291 PRO 1291 VCTN 1 B7H4 B7-H4 PRO-1291 recombinant recombinant-proteins proteins protein

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