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HA-100

Name: HA-100
Brand: TargetMol
SKU: T7648
Price: 238 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T7648Cas号 84468-24-6 一键复制产品信息纯度: 99.44%

很棒

HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。

HA-100

一键复制产品信息

很棒

纯度: 99.44%

货号 T7648Cas号 84468-24-6

HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。

规格	价格	库存
1 mg	¥ 238	现货
5 mg	¥ 555	现货
10 mg	¥ 888	现货
25 mg	¥ 1,770	现货
50 mg	¥ 2,730	现货
100 mg	¥ 3,990	现货
1 mL x 10 mM (in DMSO)	¥ 583	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.44%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

HA-100 AI Summary

HA-100 exhibits significant pharmacological activity across various biological targets. It demonstrates a binding affinity to the human adenosine A3 receptor in HEK293 cells with a Ki value of 25000.0 nM. This compound also acts as an inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with IC50 values of 12000.0 nM and 6000.0 nM, respectively. Additionally, it shows antimalarial activity against drug-resistant Plasmodium falciparum strains D6 and W2 with IC50 values greater than 36000.0 nM and 4300.0 nM, respectively. Further bioactivity assays reveal that HA-100 inhibits Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 39810.7 nM, and Cytochrome P450 2C19 (CYP2C19) with a potency of 10000.0 nM. It also functions as both an activator and inhibitor/substrate of Cytochrome P450 3A4 (CYP3A4) with potencies of 12589.3 nM. Moreover, it modulates lipid storage with a potency of 15848.9 nM, and inhibitis human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 29855.4 nM and 33498.3 nM in the absence and presence of CPT, respectively. In antiviral assays, HA-100 inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, though the inhibition percentages are relatively low at -4.72% and 0.17% at a concentration of 10 µM after 48 hours. Moreover, it shows 12.96% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM using a FRET-based assay with a peptide substrate. Finally, HA-100 shows 15.11% inhibition of human HDAC6 in an enzymatic assay using a commercial peptide substrate, but exhibits -3.91% inhibition in a similar assay using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	HA-100 is an inhibitor of protein kinase
靶点活性	PKG:4 μM , PKC:12 μM, PKC:6.5 μM (Ki), MLCK:240 μM , MLCK:61 μM (Ki), PKA:8 μM

化学信息

分子量	277.34
分子式	C₁₃H₁₅N₃O₂S
CAS No.	84468-24-6
Smiles	O=S(=O)(N1CCNCC1)c1cccc2cnccc12
密度	1.332 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 150 mg/mL (540.85 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6057 mL	18.0284 mL	36.0568 mL	180.2841 mL
5 mM	0.7211 mL	3.6057 mL	7.2114 mL	36.0568 mL
10 mM	0.3606 mL	1.8028 mL	3.6057 mL	18.0284 mL
20 mM	0.1803 mL	0.9014 mL	1.8028 mL	9.0142 mL
50 mM	0.0721 mL	0.3606 mL	0.7211 mL	3.6057 mL
100 mM	0.0361 mL	0.1803 mL	0.3606 mL	1.8028 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。