Eticlopride hydrochloride

Name: Eticlopride hydrochloride
Brand: TargetMol
SKU: T4007
Price: 412 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98%

货号 T4007Cas号 97612-24-3

别名 依替必利盐酸盐

Eticlopride hydrochloride 是一种抗精神病药，是一种选择性多巴胺 D2/D3 受体拮抗剂（Ki：0.5/0.16 nM）。

Eticlopride hydrochloride

一键复制产品信息

很棒

纯度: 98%

货号 T4007 别名 依替必利盐酸盐Cas号 97612-24-3

Eticlopride hydrochloride 是一种抗精神病药，是一种选择性多巴胺 D2/D3 受体拮抗剂（Ki：0.5/0.16 nM）。

规格	价格	库存	数量
1 mg	¥ 412	现货
5 mg	待询	现货

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纯度: 98%

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产品介绍

Eticlopride hydrochloride AI Summary

Eticlopride hydrochloride exhibits a broad range of bioactivities, including antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 10000.0 nM to 12589.25 nM after 72 hours, as determined by the SYBR green assay. It has shown potency in inhibiting interactions of HP1-beta chromodomain with methylated histone tails, bacterial growth inhibition, cytotoxicity in TGF-b, cell surface uPA generation, induction of DNA re-replication in breast cells, inhibition of mitochondrial permeability transition pore, inhibition of Glutaminase, inhibition of Hepatitis C Virus, inhibition of ATXN expression, and inhibition of GLP-1 Receptor. Furthermore, Eticlopride hydrochloride induces synthetic lethality in tumor cells producing 2HG, inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1), and has demonstrated efficacy against Lassa Virus, Marburg Virus, and Ebola Virus by inhibiting their binding or entry into cells. Additionally, Eticlopride hydrochloride has shown antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 47.59% at a concentration of 10 µM after 48 hours and shows 12.59% inhibition of SARS-CoV-2 3CL-Pro protease at a 20 µM concentration, as determined by FRET-based assay. In Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), it achieved an inhibition index of 0.4234 after a certain multiplicity of infection (MOI) after 72 hours, and demonstrated largely negligible inhibition (-0.09%) of cytotoxicity in VERO-6 cells at the same concentration and exposure duration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM).
靶点活性	D2:0.50 nM, D2:0.09 nM (Ki), D3:0.16 nM
别名	依替必利盐酸盐

化学信息

分子量	377.31
分子式	C₁₇H₂₅ClN₂O₃.HCl
CAS No.	97612-24-3
Smiles	Cl.CCN1CCC[C@H]1CNC(=O)c1c(O)c(CC)cc(Cl)c1OC
密度	no data available

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 30 mg/mL (79.51 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.3 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6503 mL	13.2517 mL	26.5034 mL	132.5170 mL
5 mM	0.5301 mL	2.6503 mL	5.3007 mL	26.5034 mL
10 mM	0.2650 mL	1.3252 mL	2.6503 mL	13.2517 mL
20 mM	0.1325 mL	0.6626 mL	1.3252 mL	6.6259 mL
50 mM	0.0530 mL	0.2650 mL	0.5301 mL	2.6503 mL