Name: Peruvoside
Brand: TargetMol
SKU: T126270
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 1,980

5日内发货

5 mg

¥ 3,250

In stock

产品介绍

生物活性

产品描述	Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
体外活性	方法：Peruvoside（5,10,50nM,24小时）处理A549 肺癌细胞系，WestrenBlot分析相关蛋白的表达。结果：Peruvoside在 A549 细胞中抑制 Src、EGFR 和 STAT3 的蛋白表达和磷酸化。[1]
体内活性	方法：Peruvoside（0.1 mg/kg，腹腔注射，每天，28天）处理A549细胞皮下注射的肿瘤异种移植模型裸鼠。随后每7天观察一次以监测肿瘤生长情况。结果：Peruvoside治疗组的平均肿瘤大小为129.9 mm³（95% CI = 86-174 mm³；P = 0.0068），显著小于对照组（348 mm³，95% CI = 189-507 mm³）；肿瘤重量也显著降低，从对照组的0.55克降至Peruvoside治疗组的0.26克（P = 0.0126）。[1]
别名	黄夹次苷, Encordin

化学信息

分子量	548.67
分子式	C₃₀H₄₄O₉
CAS No.	1182-87-2
Smiles	C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@@]1(C[C@@H](O[C@H]6[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O6)CC2)[H])[H])[H]
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200.00 mg/mL (364.52 mM), Sonication and heating are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8226 mL	9.1129 mL	18.2259 mL	91.1295 mL
5 mM	0.3645 mL	1.8226 mL	3.6452 mL	18.2259 mL
10 mM	0.1823 mL	0.9113 mL	1.8226 mL	9.1129 mL
20 mM	0.0911 mL	0.4556 mL	0.9113 mL	4.5565 mL
50 mM	0.0365 mL	0.1823 mL	0.3645 mL	1.8226 mL
100 mM	0.0182 mL	0.0911 mL	0.1823 mL	0.9113 mL

体内实验配液计算器