Name: Peruvoside
Brand: TargetMol
SKU: T126270
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 1,980

5日内发货

5 mg

¥ 3,250

5日内发货

生物活性

产品描述	Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G₂/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
体外活性	方法：Peruvoside（5,10,50nM,24小时）处理A549 肺癌细胞系，WestrenBlot分析相关蛋白的表达。结果：Peruvoside在 A549 细胞中抑制 Src、EGFR 和 STAT3 的蛋白表达和磷酸化。[1]
体内活性	方法：Peruvoside（0.1 mg/kg，腹腔注射，每天，28天）处理A549细胞皮下注射的肿瘤异种移植模型裸鼠。随后每7天观察一次以监测肿瘤生长情况。结果：Peruvoside治疗组的平均肿瘤大小为129.9 mm³（95% CI = 86-174 mm³；P = 0.0068），显著小于对照组（348 mm³，95% CI = 189-507 mm³）；肿瘤重量也显著降低，从对照组的0.55克降至Peruvoside治疗组的0.26克（P = 0.0126）。[1]
别名	黄夹次苷, Encordin

化学信息

分子量	548.67
分子式	C₃₀H₄₄O₉
CAS No.	1182-87-2
Smiles	C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@@]1(C[C@@H](O[C@H]6[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O6)CC2)[H])[H])[H]
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (364.52 mM), Sonication and heating are recommended.

溶液配制表

DMSO