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顶部相关产品产品介绍化学信息储存和溶解信息计算器

(±)-1,2-Propanediol

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货号 T5619Cas号 57-55-6

别名 丙二醇, Propylene glycol, Methyl ethyl glycol, 1,2-Propanediol, 1,2-Dihydroxypropane

(±)-1,2-Propanediol 是一种脂肪族醇，具有多种作用，可作为防腐剂和防冻剂，在食品工业和护肤品行业应用广泛。 (±)-1,2-Propanediol 是一种天然抑菌剂，能够在一定程度上抑制细菌的生长和繁殖

(±)-1,2-Propanediol
其他形式的 “(±)-1,2-Propanediol”:
Propylene glycol monostearate
Propylene glycol dilaurate
Propylene Glycol Monostearate (Standard)
(±)-1,2-Propanediol (Standard)
(±)-1,2-Propanediol-d6
(±)-1,2-Propanediol-d8
(R)-(-)-1,2-Propanediol
(S)-(+)-1,2-Propanediol

(±)-1,2-Propanediol

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Rating icon 很棒
货号 T5619 别名 丙二醇, Propylene glycol, Methyl ethyl glycol, 1,2-Propanediol, 1,2-DihydroxypropaneCas号 57-55-6

(±)-1,2-Propanediol 是一种脂肪族醇，具有多种作用，可作为防腐剂和防冻剂，在食品工业和护肤品行业应用广泛。 (±)-1,2-Propanediol 是一种天然抑菌剂，能够在一定程度上抑制细菌的生长和繁殖

规格价格库存数量
50 mL
¥ 295
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产品介绍

(±)-1,2-Propanediol AI Summary
(±)-1,2-Propanediol has been evaluated for eye irritation potential using the Draize in vivo rabbit eye irritation test, showing a mean eye score (MES) of 0.1, which suggests low eye irritation potential. It demonstrates anticonvulsant activity by providing protection against maximal electroshock-induced seizures in Charles Foster rats at a dose of 30 mg/kg intraperitoneally. However, this protection is observed with an activity level of 0.0% and a significant impact on the rotarod test performance (0.03333 hours). Biologically, (±)-1,2-Propanediol exhibits a wide range of activities: - It inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 5011.9 nM. - It shows cytotoxicity in live cells with a potency of 3981.1 nM in the MultiTox-Fluor Cytotoxicity assay. - It modulates lipid storage in Drosophila S3 cells (580.5 nM potency). - It acts against delayed death of the malarial parasite plastid (11689.1 nM potency). - It interacts with HP1-beta Chromodomain and methylated histone tails (89125.1 nM potency). - It antagonizes the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway (7497.8 nM potency). - It exhibits agonist activity at TRPA1 with 12.0% activity at 1000 µM relative to AITC. - It has antiviral activity against SARS-CoV-2 with an IC50 greater than 20000.0 nM. The compound impacts multiple organ systems and physiological processes, including liver and kidney function, lipid metabolism, enzyme activity, blood cell counts, and immune responses. It binds to various receptors and enzymes, showing antagonistic activity at human TBXA2R and several other receptors, agonist activity at ADRA1A and CHRM1, and inhibition of enzymes like PTGS1, PDE3A, PDE4A, and MAOA. (±)-1,2-Propanediol has a hydrophilic nature indicated by its low oil-water partition coefficient (LogP = -2.77) and even lower ethyl ether-water partition coefficient (LogP = -1.74), suggesting higher solubility in water or polar solvents..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
(±)-1,2-Propanediol is an aliphatic alcohol that has a variety of roles as a preservative and antifreeze, and has a wide range of applications in the food industry and skin care industry. (±)-1,2-Propanediol is a natural bacteriostatic agent that inhibits the growth and multiplication of bacteria to a certain extent.
别名丙二醇, Propylene glycol, Methyl ethyl glycol, 1,2-Propanediol, 1,2-Dihydroxypropane
化学信息
分子量76.09
分子式C3H8O2
CAS No.57-55-6
SmilesC(CO)(C)O
密度1.036 g/cm3 at 25℃ (lit.)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 250 mg/mL (3285.58 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM13.1423 mL65.7117 mL131.4233 mL657.1166 mL
5 mM2.6285 mL13.1423 mL26.2847 mL131.4233 mL
10 mM1.3142 mL6.5712 mL13.1423 mL65.7117 mL
20 mM0.6571 mL3.2856 mL6.5712 mL32.8558 mL
50 mM0.2628 mL1.3142 mL2.6285 mL13.1423 mL
100 mM0.1314 mL0.6571 mL1.3142 mL6.5712 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Inhibitorinhibit1,2-Propylene glycol(±)1,2Propanediol(±) 1,2 Propanediol
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