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Desipramine hydrochloride

Name: Desipramine hydrochloride
Brand: TargetMol
SKU: T0991
Price: 125 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.96%

货号 T0991Cas号 58-28-6

别名 盐酸去甲咪嗪, NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine

Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。

Desipramine hydrochloride

一键复制产品信息

很棒

纯度: 99.96%

货号 T0991 别名 盐酸去甲咪嗪, NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, DesmethylimipramineCas号 58-28-6

规格	价格	库存
25 mg	¥ 186	现货
50 mg	¥ 272	现货
100 mg	¥ 354	现货
200 mg	¥ 496	现货
1 mL x 10 mM (in DMSO)	¥ 125	现货

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纯度: 99.96%

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COA LCMS HNMR 产品操作手册

产品介绍

Desipramine hydrochloride AI Summary

Desipramine hydrochloride exhibits a wide range of bioactivities across various biological systems. It has shown significant inhibitory effects on neurotransmitter systems, such as the inhibition of tetrabenazine (TBZ)-induced depression of motor activity (ED50: 0.07 mg/kg), TBZ-induced ptosis in mice (ED50: 0.05 mg/kg), and serotonin uptake (Ki: 182.0 nM). It also effectively inhibits the norepinephrine transporter (Ki: 0.8 nM) and norepinephrine uptake (Ki: 0.65 nM) into rat brain synaptosomes. Additionally, it inhibits dopamine uptake with a Ki of 6532.0 nM. The compound shows an anticholinergic effect on tetrabenazine-treated mice by reducing pupil size. Furthermore, Desipramine hydrochloride exhibits strong antiplasmodial activity against various Plasmodium falciparum strains, suggesting potential as an antimalarial agent. It also demonstrates antiviral activity against SARS-CoV-2, including inhibition of cytotoxicity in Caco-2 cells (16.78% inhibition) and VERO-6 cells, as well as inhibition of the SARS-CoV-2 3CL-Pro protease (28.19% at 20 μM). Its antibacterial properties vary across different strains, showing the most significant inhibition against Acinetobacter baumannii (28.7%). The compound also affects cellular protein expressions and signaling pathways, inhibiting targets such as SMN2 splice variant expression, Lassa virus infection, and more. It is permeable with a logP value of 4.54 and exhibits cytotoxicity against human HepG2 cells with an IC50 of 11400.0 nM. This diverse pharmacological profile highlights its potential for further development in treating diseases involving neurotransmitter dysregulation, infectious diseases, and cancer..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
靶点活性	SERT:61 nM (Ki), NET:4 nM (Ki), DAT:78720 nM (Ki)
别名	盐酸去甲咪嗪, NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine

化学信息

分子量	302.84
分子式	C₁₈H₂₃ClN₂
CAS No.	58-28-6
Smiles	Cl.CNCCCN1c2ccccc2CCc2ccccc12
密度	no data available
颜色	Gray
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 252.00 mg/mL (832.12 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.30 mg/mL (10.90 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3021 mL	16.5104 mL	33.0207 mL	165.1037 mL
5 mM	0.6604 mL	3.3021 mL	6.6041 mL	33.0207 mL
10 mM	0.3302 mL	1.6510 mL	3.3021 mL	16.5104 mL
20 mM	0.1651 mL	0.8255 mL	1.6510 mL	8.2552 mL
50 mM	0.0660 mL	0.3302 mL	0.6604 mL	3.3021 mL
100 mM	0.0330 mL	0.1651 mL	0.3302 mL	1.6510 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Desipramine hydrochloride

Desipramine hydrochloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Desipramine hydrochloride

Desipramine hydrochloride