Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-IN-PP1是一种针对蛋白激酶D(PKD)家族成员PKD1、PKD2和PKD3具有高效抑制作用的抑制剂,IC50值分别为108、94和108 nM。此外,3-IN-PP1作为一种广谱抗癌剂,能抑制多种肿瘤细胞的生长,适用于癌症研究领域。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 7,380 | 10-14周 | ||
50 mg | ¥ 9,590 | 10-14周 | ||
100 mg | ¥ 14,800 | 10-14周 |
产品描述 | 3-IN-PP1, a potent protein kinase D (PKD) inhibitor, exhibits pan-PKD inhibitory activity with IC50 values of 108 nM for PKD1, 94 nM for PKD2, and 108 nM for PKD3. Additionally, it serves as a broad-spectrum anticancer agent by inhibiting the growth of various tumor cells. 3-IN-PP1 is utilized in cancer research [1]. |
体外活性 | 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC 50 values of 108, 94 and 108 nM, respectively [1]. 3-IN-PP1 (5 μM, 0-114 h) displays potent anti-proliferative activity against PANC-1 cells [1]. 3-IN-PP1 (20 μM, 1 h) potently blocks PKD-dependent cortactin phosphorylation in PANC-1 cells [1]. 3-IN-PP1 has inhibition of different tumor cell growth with IC 50 values range from 1.6 to 39.2μM [1]. Cell Proliferation Assay [1] Cell Line: PANC-1 cell Concentration: 5 μM Incubation Time: 0-114 h Result: Significantly inhibited PANC-1 cell proliferation after incubation for 96 and 144 hours. Western Blot Analysis [1] Cell Line: PANC-1 cells Concentration: 20 μM Incubation Time: 1 h Result: Reduced cortactin phosphorylation in PANC-1 cells. |
分子量 | 306.36 |
分子式 | C17H18N6 |
CAS No. | 2227110-54-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
3-IN-PP1 2227110-54-3 Inhibitor inhibitor inhibit