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Liranaftate

Name: Liranaftate
Brand: TargetMol
SKU: T1497
Price: 421 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.97%

货号 T1497Cas号 88678-31-3

别名 利拉萘酯, Piritetrate, M-732

Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂，可研究皮肤癣菌。

为众多的药物研发团队赋能，

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Liranaftate

一键复制产品信息

很棒

纯度: 99.97%

货号 T1497 别名 利拉萘酯, Piritetrate, M-732Cas号 88678-31-3

Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂，可研究皮肤癣菌。

规格	价格	库存
5 mg	¥ 421	现货
10 mg	¥ 682	现货
25 mg	¥ 1,390	现货
50 mg	¥ 2,515	现货
100 mg	¥ 3,775	现货
200 mg	¥ 5,218	现货
1 mL x 10 mM (in DMSO)	¥ 515	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA HNMR LCMS 产品操作手册

产品介绍

Liranaftate AI Summary

Liranaftate exhibits a range of bioactivities, making it a versatile compound for research and development. It exhibits potent inhibition of Plasmodium falciparum proliferation and moderate inhibition of tyrosyl-DNA phosphodiesterase 1 (TDP1) and histone lysine methyltransferase G9a. It shows weak inhibition of Lamin A splicing and USP1/UAF1. Additionally, Liranaftate blocks the entry of Ebola Virus and Marburg Virus, as well as demonstrates activity in Schwann cell assays. In relation to antiviral activities, Liranaftate shows significant action against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Vero E6 and Caco-2 cells. It demonstrated a 6.52% inhibition of cytotoxicity in Caco-2 cells at 10 µM concentration after 48 hours and an IC50 greater than 20000 nM in Vero E6 cells. The compound also inhibits SARS-CoV-2 3CL-Pro protease activity by 13.93% at 20 µM concentration. Liranaftate has a solubility of 12,500 nM in a pH 6.5 phosphate buffer containing 5% DMSO and showed 0% inhibition of IDO1 in L-tryptophan substrate assays. It inhibits the cell viability of Vero E6 cells infected with SARS-CoV-2, though with lower activity relative to an arbidol control—inhibition index of 0.6869 after 72 hours. The compound exhibits a binding affinity towards various receptors and transporters with notable affinity towards human OPRK1 (AC50 = 1500 nM) and human NR1I2 (AC50 = 1100 nM), and inhibition of human MAOA (AC50 = 17999.9 nM). Lastly, it also shows inhibitory bioactivity on human HDAC6 with inhibition percentages of -13.41% and -11.72% in enzymatic assays using different peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is essential for cell membrane integrity. By preventing ergosterol synthesis and causing accumulation of squalene, this agent increases cell membrane permeability, cell leakage and eventually cell lysis.

别名

利拉萘酯, Piritetrate, M-732

化学信息

分子量	328.43
分子式	C₁₈H₂₀N₂O₂S
CAS No.	88678-31-3
Smiles	COc1cccc(n1)N(C)C(=S)Oc1ccc2CCCCc2c1
密度	1.24g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9 mg/mL (27.4 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 0.5 mg/mL (1.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0448 mL	15.2239 mL	30.4479 mL	152.2394 mL
5 mM	0.6090 mL	3.0448 mL	6.0896 mL	30.4479 mL
10 mM	0.3045 mL	1.5224 mL	3.0448 mL	15.2239 mL
20 mM	0.1522 mL	0.7612 mL	1.5224 mL	7.6120 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。