Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3 inhibitor 3 是一种具有选择性、具有口服活性和脑渗透性的 GSK-3 抑制剂,对 GSK-3α 和 GSK-3β 具有抑制作用, IC50s 分别为 0.35 nM 和 0.25 nM。GSK-3 inhibitor 3 在三重转基因小鼠阿尔茨海默病模型中降低 Tau 蛋白 (tau protein) S396 磷酸化水平,IC50为 10 nM。GSK-3 inhibitor 3 可用于研究神经系统疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,290 | 现货 | ||
25 mg | ¥ 6,890 | 现货 | ||
50 mg | ¥ 9,320 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 24,900 | 现货 |
产品描述 | GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau protein S396 with an IC50 of 10 nM in a triple transgenic mouse model of Alzheimer's disease. GSK-3 inhibitor 3 reduced the phosphorylation level of tau protein S396 in a triple transgenic mouse model of Alzheimer's disease, with an IC50 of 10 nM.GSK-3 inhibitor 3 can be used for the study of neurological diseases. |
靶点活性 | GSK-3β:0.25 nM, GSK-3α:0.35 nM, CDK2:0.22 μM, CDK5:1.3 μM |
体外活性 | GSK-3 inhibitor 3 (Compound 34) (1 μM) is a highly selective inhibitor of CDK2 and CDK5 with IC50s of 0.22 μM and 1.3 μM for CDK2 and CDK5, respectively.[1] |
体内活性 |
GSK-3 inhibitor 3 (Compound 34) (2 mg/kg; i.v.;10 mg/kg orally; Alzheimer’s disease model using LaFerla 3xTg-C57BL6 mice) demonstrated a T1/2 of 2.5 hours (i.v.) in male C57BL6 mice and an oral bioavailability (F%) of approx. 100%.[1] GSK-3 inhibitor 3 (10 mg/kg, single oral dose) reduces Tau 396 phosphorylation levels by 33% in a triple transgenic mouse model of Alzheimer's disease.[1] |
分子量 | 410.4 |
分子式 | C23H15FN6O |
CAS No. | 2227279-84-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSK-3 inhibitor 3 2227279-84-5 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells GSK-3 Microtubule Associated GSK3inhibitor3 Inhibitor inhibitor inhibit