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β-Cyclodextrin

Name: β-Cyclodextrin
Brand: TargetMol
SKU: T2951
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T2951Cas号 7585-39-9

别名 β-环糊精, NSC 269471, Cyclomaltoheptaose, beta-环糊精, Betadex, Beta-Cyclodextrin

β-Cyclodextrin (NSC 269471) 是一种环状多糖，由 α-D-吡喃型葡萄糖单元通过 α-(1,4) 糖苷键连接而成，通常用于增强药物的溶解度，可抑制流感病毒H1N1。

β-Cyclodextrin

一键复制产品信息

很棒

纯度: 99.92%

货号 T2951 别名 β-环糊精, NSC 269471, Cyclomaltoheptaose, beta-环糊精, Betadex, Beta-CyclodextrinCas号 7585-39-9

β-Cyclodextrin (NSC 269471) 是一种环状多糖，由 α-D-吡喃型葡萄糖单元通过 α-(1,4) 糖苷键连接而成，通常用于增强药物的溶解度，可抑制流感病毒H1N1。

规格	价格	库存	数量
1 g	¥ 99	现货
5 g	¥ 175	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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实验操作小课堂

常见问题解答

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纯度: 99.92%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

β-Cyclodextrin AI Summary

β-Cyclodextrin exhibits a variety of bioactivities and pharmacokinetic properties. It is known to catalyze the hydrolysis of p-nitrophenyl phosphate (p-NPP) in the presence of zinc ions (Zn²⁺) at 37°C, with a pseudo-first-order rate constant (k_obs) of 4.16E-7 s⁻¹. In rats, the compound shows a rapid time to reach maximum plasma concentration (Tmax = 1.5 hr), a high Cmax of 9251.18 nM, and a relatively long mean residence time (MRT = 5.9 hr), with an area under the concentration-time curve (AUC) of 63300.0 ng.hr.mL⁻¹, indicating prolonged plasma exposure and good oral bioavailability at 34.0%. In terms of bioactivity, β-Cyclodextrin demonstrates in vitro and in vivo reversal activity against rocuronium-induced blockage in isolated mouse hemidiaphragm and guinea pig models, with an EC50 exceeding 360,000 nM and an ED50 of 20.0 umol/kg, respectively. The compound also exhibits high survival percentages (96.4% to 96.8%) in in vitro assays against DU 145 cells, indicating non-significant cytotoxic effects. Moreover, the compound has antioxidant properties, inhibiting copper-induced human LDL peroxidation and malondialdehyde production in a dose-dependent manner, ranging from 0.11% at 2 µM to 10.72% at 200 µM. It also induces Escherichia coli pUC19 DNA cleavage and inhibits synthetic amyloid beta-42 fibrillation. β-Cyclodextrin shows bioactivity as an inhibitor and agonist in various assays: - Potency of 1.3 nM in the Cell Viability assay - Potency of 15.8 nM as an agonist of the Thyroid Stimulating Hormone Receptor - Potency of 39810.7 nM as an inhibitor of ALDH1A1 - Potency of 56234.1 nM as an inhibitor of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) - Potency of 44668.4 nM as an antagonist of farnesoid X receptor signaling - AC50 of 2.818 µM and 1.995 µM in assays for blocking Ebola Virus entry Additionally, it shows properties related to diffusion coefficients in different solvent systems and has an aqueous solubility of 1.85 g per 100 ml at room temperature. In antibacterial assays against Staphylococcus aureus, it exhibits membrane disruption and antibacterial activity. β-Cyclodextrin also shows anti-viral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells with various inhibition rates and IC50 values greater than 20,000.0 nM. It also weakly inhibits human HDAC6 enzymatic activity with slight inhibition percentages. Overall, β-Cyclodextrin displays a broad spectrum of bioactivities including enzyme inhibition, antioxidant, antiviral, and potential therapeutic properties with favorable pharmacokinetic profiles in preclinical models..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.
别名	β-环糊精, NSC 269471, Cyclomaltoheptaose, beta-环糊精, Betadex, Beta-Cyclodextrin

化学信息

分子量	1134.98
分子式	C₄₂H₇₀O₃₅
CAS No.	7585-39-9
Smiles	C(O)[C@@H]1[C@@]2([C@H](O)C(O)[C@](O1)(O[C@@]3([C@@H](CO)O[C@@]([C@H](O)[C@H]3O)(O[C@@]4([C@@H](CO)O[C@@]([C@H](O)[C@H]4O)(O[C@@]5([C@@H](CO)O[C@](O[C@]6([C@H](O)[C@@H](O)[C@@](O[C@]7([C@H](O)[C@@H](O)[C@@](O[C@]8([C@H](O)[C@@H](O)[C@@](O2)(O[C@@H]8CO)[H])[H])(O[C@@H]7CO)[H])[H])(O[C@@H]6CO)[H])[H])([C@H](O)[C@H]5O)[H])[H])[H])[H])[H])[H])[H])[H]
密度	1.44 g/cm3. Temperature:20 °C.
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 9.71 mg/mL (8.56 mM), Sonication is recommended.

DMSO: 55 mg/mL (48.46 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8811 mL	4.4054 mL	8.8107 mL	44.0536 mL
5 mM	0.1762 mL	0.8811 mL	1.7621 mL	8.8107 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.0881 mL	0.4405 mL	0.8811 mL	4.4054 mL
20 mM	0.0441 mL	0.2203 mL	0.4405 mL	2.2027 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

β-Cyclodextrin βCyclodextrin β Cyclodextrin NSC-269471 NSC269471 Inhibitor inhibit InfluenzaVirus Influenza Virus b-Cyclodextrin

β-Cyclodextrin

β-Cyclodextrin

β-Cyclodextrin 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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