规格

价格

库存

数量

5 mg

¥ 228

现货

10 mg

¥ 326

现货

25 mg

¥ 587

现货

50 mg

¥ 840

现货

1 mL x 10 mM (in DMSO)

¥ 326

现货

生物活性

产品描述	Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms.
体内活性	Lofexidine 与安慰剂相比显著降低了SOWS评分，并在经历阿片类药物撤退的参与者中展现了更好的保留率。Lofexidine 潜在提供了一个有益的非阿片类替代品，用于治疗阿片类药物撤退症状[1]。
动物实验	8-day, randomized, double-blind, placebo-controlled, parallel-group study in 264 patients dependent on short-acting opioids evaluated the efficacy of lofexidine hydrochloride in reducing withdrawal symptoms in patients undergoing opioid withdrawal.?The primary efficacy measures were SOWS-Gossop on Day 3 and time-to-dropout.?Secondary endpoints included the proportion of participants who were completers;?area under the 5-day SOWS-Gossop - time curve (i.e., AUC1-5), and daily mean SOWS-Gossop, OOWS-Handelsman, MCGI (subject and rater), and VAS-E scores.?Participants received lofexidine HCl 3.2mg daily in four divided doses or matching placebo on Days 1-5, followed by 2days of placebo[1].
别名	洛非西定

化学信息

分子量	259.13
分子式	C₁₁H₁₂Cl₂N₂O
CAS No.	31036-80-3
Smiles	CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
密度	1.39g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 62.5 mg/mL (241.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.72 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8591 mL	19.2953 mL	38.5907 mL	192.9533 mL
5 mM	0.7718 mL	3.8591 mL	7.7181 mL	38.5907 mL
10 mM	0.3859 mL	1.9295 mL	3.8591 mL	19.2953 mL
20 mM	0.1930 mL	0.9648 mL	1.9295 mL	9.6477 mL
50 mM	0.0772 mL	0.3859 mL	0.7718 mL	3.8591 mL
100 mM	0.0386 mL	0.1930 mL	0.3859 mL	1.9295 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Lofexidine

Lofexidine

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Lofexidine

Lofexidine

Lofexidine 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词