SARS-CoV-2-IN-13

Name: SARS-CoV-2-IN-13
Brand: TargetMol
SKU: T60919
Price: 297 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.54%

货号 T60919Cas号 56961-10-5

SARS-CoV-2-IN-13 (compound 6) 是氯硝柳胺的类似物。在人血浆和肝S9酶测定中，SARS-CoV-2-IN-13 比氯硝柳胺更稳定。SARS-CoV-2-IN-13 口服给药时可以提高生物利用度和半衰期。SARS-CoV-2-IN-13 是SARS-CoV-2的有效抑制剂，IC50值为 0.057 μM。

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SARS-CoV-2-IN-13

一键复制产品信息

很棒

纯度: 98.54%

货号 T60919Cas号 56961-10-5

规格	价格	库存
1 mg	¥ 297	现货
5 mg	¥ 738	现货
10 mg	¥ 1,190	现货
25 mg	¥ 2,390	现货
50 mg	¥ 3,400	现货
100 mg	¥ 4,750	现货
200 mg	¥ 6,390	现货
1 mL x 10 mM (in DMSO)	¥ 549	现货

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产品介绍

SARS-CoV-2-IN-13 AI Summary

SARS-CoV-2-IN-13 demonstrates significant antiviral activity, cytotoxicity, metabolic stability, and permeability across various assays. It exhibits cytotoxicity against human A549 cells with a CC50 of 15100 nM and antiviral activity against Human adenovirus 5 in 293beta5 cells with an IC50 of 1000 nM, showing a high selectivity ratio of 15.1. The compound also inhibits NS-1 and envelope proteins in Zika virus with IC50 values of 2170 nM and 2870 nM, respectively. Against SARS-CoV-2, it reveals an IC50 of 57 nM in Vero cells and a CC50 of 1510 nM in Vero E6 cells, resulting in a selectivity ratio of 26.5. An additional cytotoxicity assay with SARS-CoV-2 preincubation reports a CC50 of 64200 nM. The permeability is measured at 68.0 x 10^-6 cm/s in a PAMPA assay and 12.3 x 10^-6 cm/s against SARS-CoV-2, while solubility varies from less than 1.0 ug/mL to 5.1 ug/mL in water. The compound shows metabolic stability in rat liver microsomes for 3.8 minutes and retains 78% stability in human plasma and 41% in human liver microsomes S9 fraction after 360 minutes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

SARS-CoV-2-IN-13 (compound 5) is an analogue of niclosamide. SARS-CoV-2-IN-13 is more stable than niclosamide in human plasma and liver S9 enzymes assay. SARS-CoV-2-IN-13 can improve bioavailability and half-life when administered orally. SARS-CoV-2-IN-13 is a potent SARS-CoV-2 inhibitor with an IC 50 of 0.057 μM [1].

化学信息

分子量	327.12
分子式	C₁₃H₈Cl₂N₂O₄
CAS No.	56961-10-5
Smiles	Oc1ccc(Cl)cc1C(=O)Nc1ccc(c(Cl)c1)[N+]([O-])=O

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 112.5 mg/mL (343.91 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0570 mL	15.2849 mL	30.5698 mL	152.8491 mL
5 mM	0.6114 mL	3.0570 mL	6.1140 mL	30.5698 mL
10 mM	0.3057 mL	1.5285 mL	3.0570 mL	15.2849 mL
20 mM	0.1528 mL	0.7642 mL	1.5285 mL	7.6425 mL
50 mM	0.0611 mL	0.3057 mL	0.6114 mL	3.0570 mL
100 mM	0.0306 mL	0.1528 mL	0.3057 mL	1.5285 mL