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Valpromide

Name: Valpromide
Brand: TargetMol
SKU: T0355
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.72%

货号 T0355Cas号 2430-27-5

别名 丙戊酰胺, Valpramide, Dipropylacetamide, Depamide, 2-propylpentanamide

Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。

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Valpromide

一键复制产品信息

很棒

纯度: 99.72%

货号 T0355 别名 丙戊酰胺, Valpramide, Dipropylacetamide, Depamide, 2-propylpentanamideCas号 2430-27-5

Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。

规格	价格	库存
10 mg	¥ 225	现货
25 mg	¥ 263	现货
50 mg	¥ 297	现货
100 mg	¥ 397	现货
500 mg	¥ 991	现货
1 g	¥ 1,470	现货
1 mL x 10 mM (in DMSO)	¥ 198	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.72%

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COA HNMR LCMS 产品操作手册

产品介绍

Valpromide AI Summary

Valpromide exhibits a diverse range of bioactivities across multiple biological targets and assays. In anticonvulsant models, COMPOUND 150721 demonstrated effectiveness against maximal electroshock seizures in mice, with an ED50 of 14.9 mg/kg after 30 minutes of intraperitoneal administration and 11.4 mg/kg after 3 hours. The substance also showed protective effects against seizures induced by scMet and displayed antiepileptic activity in CF1 mice (ED50 of 32.0 mg/kg), with minimal motor impairment at higher doses, indicating a good safety margin. Additionally, the compound exhibits antiallodynic activity in a rat model of spinal nerve ligation-induced neuropathic pain with an ED50 of 61.0 mg/kg. Valpromide inhibited Glycogen synthase kinase-3 alpha by 80.0% and Glycogen synthase kinase-3 beta by 35.5%. It also demonstrated 50.9% inhibition of microsomal epoxide hydrolase in human liver microsomes when tested with styrene oxide. In antiviral assays, Valpromide showed varying degrees of inhibition against SARS-CoV-2. Specifically, it inhibited cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of 0.27% and 0.05% at 10 µM concentration after 48 hours, respectively. The compound also had a bioactivity of inhibiting SARS-CoV-2 3CL-Pro protease at a rate of 9.975% at 20 µM. Furthermore, Valpromide showed an inhibitory action on human HDAC6 enzyme, demonstrating 0.83% inhibition with a commercial peptide substrate and 48.98% with a custom peptide substrate. It also displayed binding affinity towards various human and rat receptors and ion channels, with AC50 values greater than 10,000 nM, and exhibited activity as both an antagonist and agonist at receptors such as human CHRM2, HTR1A, ADRA1A, ADRA2A, HTR2A, HTR2B, and CNR1. Lastly, Valpromide has a solubility of 3700.0 µg/mL in water, indicating good aqueous solubility, which is beneficial for its pharmacokinetic properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.
别名	丙戊酰胺, Valpramide, Dipropylacetamide, Depamide, 2-propylpentanamide

化学信息

分子量	143.23
分子式	C₈H₁₇NO
CAS No.	2430-27-5
Smiles	C(CCC)(CCC)C(N)=O
密度	0.9636 g/cm3 (Estimated)

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (349.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9818 mL	34.9089 mL	69.8178 mL	349.0889 mL
5 mM	1.3964 mL	6.9818 mL	13.9636 mL	69.8178 mL
10 mM	0.6982 mL	3.4909 mL	6.9818 mL	34.9089 mL
20 mM	0.3491 mL	1.7454 mL	3.4909 mL	17.4544 mL
50 mM	0.1396 mL	0.6982 mL	1.3964 mL	6.9818 mL
100 mM	0.0698 mL	0.3491 mL	0.6982 mL	3.4909 mL