Sulfanitran

Name: Sulfanitran
Brand: TargetMol
SKU: T1248
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.60%

货号 T1248Cas号 122-16-7

别名 乙酰磺胺对硝基苯, 磺胺硝苯

Sulfanitran 是一种用于家禽业的磺胺类抗生素。它也是一种多药耐药蛋白 2 (MRP2) 激动剂，可增加 MRP2 对雌二醇 17-β-D-葡糖醛酸的亲和力。

Sulfanitran

一键复制产品信息

很棒

纯度: 99.60%

货号 T1248 别名 乙酰磺胺对硝基苯, 磺胺硝苯Cas号 122-16-7

Sulfanitran 是一种用于家禽业的磺胺类抗生素。它也是一种多药耐药蛋白 2 (MRP2) 激动剂，可增加 MRP2 对雌二醇 17-β-D-葡糖醛酸的亲和力。

规格	价格	库存
5 mg	¥ 108	现货
10 mg	¥ 137	现货
25 mg	¥ 198	现货
50 mg	¥ 328	现货
100 mg	¥ 538	现货
500 mg	¥ 1,290	现货
1 mL x 10 mM (in DMSO)	¥ 228	现货

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纯度: 99.60%

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产品介绍

Sulfanitran AI Summary

Sulfanitran has demonstrated varied bioactivity across multiple biological targets and assays. It significantly influences human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles with an activity level of 116.0%. Additionally, it acts as an inhibitor in assays involving several proteins such as human JMJD2E, TDP1, ALDH1A1, Menin-MLL interaction in leukemia, HPGD, ROR gamma transcriptional activity, Cytochrome P450 3A4, N370S glucocerebrosidase, and S16 Schwann cell PMP22 intronic element. The compound also showed efficacy in antiviral assays against Foot and Mouth Disease Virus and Ebola Virus entry. In transport assays, Sulfanitran inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells by 61.58% and in OATP1B3-transfected CHO cells by 88.89% at 10 µM concentration. However, it does not significantly inhibit human BSEP, MRP3, and MRP4 as indicated by the high IC50 values (> 133,000.0 nM) in the respective membrane vesicle transport assays. Concerning its antiviral activity, Sulfanitran inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. At a 10 µM concentration, it shows modest inhibition rates of 5.41% and -0.21%, respectively, after 48 hours. Nevertheless, the IC50 values suggest it may require higher concentrations for significant activity against SARS-CoV-2 (> 20000.0 nM and 19952.62 nM). The compound also inhibits SARS-CoV-2 3CL-Pro protease by 6.588% at a concentration of 20 µM. Additionally, Sulfanitran exhibits inhibitory activity against human HDAC6 in enzymatic assays, showing inhibition percentages of 17.7% and 5.02% with commercial and custom peptide substrates, respectively, indicating its potential HDAC6 inhibitory bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
别名	乙酰磺胺对硝基苯, 磺胺硝苯

化学信息

分子量	335.34
分子式	C₁₄H₁₃N₃O₅S
CAS No.	122-16-7
Smiles	CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)[N+]([O-])=O
密度	1.5g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (164.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9820 mL	14.9102 mL	29.8205 mL	149.1024 mL
5 mM	0.5964 mL	2.9820 mL	5.9641 mL	29.8205 mL
10 mM	0.2982 mL	1.4910 mL	2.9820 mL	14.9102 mL
20 mM	0.1491 mL	0.7455 mL	1.4910 mL	7.4551 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9820 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4910 mL