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Dichlorphenamide

Name: Dichlorphenamide
Brand: TargetMol
SKU: T6469
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.25%

货号 T6469Cas号 120-97-8

别名 双氯非那胺, 二氯苯二磺胺, Diclofenamide, Daranide, Antidrasi

Dichlorphenamide (Diclofenamide) 是一种碳酸酐酶抑制剂。

Dichlorphenamide

一键复制产品信息

很棒

纯度: 97.25%

货号 T6469 别名 双氯非那胺, 二氯苯二磺胺, Diclofenamide, Daranide, AntidrasiCas号 120-97-8

Dichlorphenamide (Diclofenamide) 是一种碳酸酐酶抑制剂。

规格	价格	库存
5 mg	¥ 198	现货
10 mg	¥ 328	现货
25 mg	¥ 589	现货
50 mg	¥ 997	现货
100 mg	¥ 1,470	现货
200 mg	¥ 2,190	现货
500 mg	¥ 3,670	现货
1 mL x 10 mM (in DMSO)	¥ 226	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 97.25%

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COA HNMR HPLC 产品操作手册

产品介绍

Dichlorphenamide AI Summary

Dichlorphenamide exhibits inhibitory activity against a range of carbonic anhydrase (CA) enzymes, demonstrating significant potential as a CA inhibitor. The compound shows a high affinity for human carbonic anhydrase II, with a Ki value of 38.0 nM, and exhibits strong inhibition of human carbonic anhydrase IX and XII, each with Ki values of 50.0 nM. It also moderately inhibits bovine carbonic anhydrase IV (Ki = 380.0 nM) and shows comparatively weaker inhibition of human carbonic anhydrase I (Ki = 1200.0 nM). The selectivity ratio for human carbonic anhydrase II over CA IX is 0.76, indicating preferential inhibition of CA II. These findings suggest that Dichlorphenamide could be a promising candidate for therapeutic applications targeting specific CA isoforms..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
别名	双氯非那胺, 二氯苯二磺胺, Diclofenamide, Daranide, Antidrasi

化学信息

分子量	305.16
分子式	C₆H₆Cl₂N₂O₄S₂
CAS No.	120-97-8
Smiles	NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
密度	1.782 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 31 mg/mL (101.59 mM), Sonication is recommended.

DMSO: 55 mg/mL (180.23 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2770 mL	16.3848 mL	32.7697 mL	163.8485 mL
5 mM	0.6554 mL	3.2770 mL	6.5539 mL	32.7697 mL
10 mM	0.3277 mL	1.6385 mL	3.2770 mL	16.3848 mL
20 mM	0.1638 mL	0.8192 mL	1.6385 mL	8.1924 mL
50 mM	0.0655 mL	0.3277 mL	0.6554 mL	3.2770 mL
100 mM	0.0328 mL	0.1638 mL	0.3277 mL	1.6385 mL