DSM705 shows inhibitory activity against P. falciparum DHODH ( Pf DHODH, IC 50 =95 nM), P. vivax DHODH ( Pv DHODH, IC 50 =52 nM) and Pf 3D7 cells (EC 50 =12 nM), with no inhibition of the human enzyme[1].

DSM705 (3-200 mg/kg; p.o. twice a day for 6 days) provides the maximum rate of parasite killing at the dose of 50 mg/kg and fully suppresses parasitemia by days 7-8[1]. DSM705 (2.6 and 24 mg/kg; a single p.o.) exhibits high oral bioavailability (74%, 70%), apparent t 1/2 (3.4, 4.5 h) and C max (2.6, 20 μM) in Swiss outbred mice[1]. DSM705 (2.3 mg/kg; a single i.v.) exhibits plasma clearance (CL=2.8 mL/min/kg) and V ss (1.3 L/kg) in mice[1]. Animal Model: SCID mice were inoculated with parasites[1]Dosage: 3, 10, 20, 50, 100, 200 mg/kg Administration: P.o. twice a day for 6 days Result: Killed parasite in a dose dependent manner and fully suppressed parasitemia by days 7-8. Animal Model: Swiss Outbred Mice[1]Dosage: 2.6 and 24 mg/kg for p.o.; 2.3 mg/kg for i.v. (Pharmacokinetic Analysis) Administration: A single p.o. and i.v. Result: P.o.: F=74/70%, t 1/2 =3.4/4.5 h, C max =2.6/20 μM. I.v.: CL=2.8 mL/min/kg, V ss =1.3 L/kg.