Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1]. |
体外活性 | VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC 50 s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively [1]. |
体内活性 | VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models [1]. |
分子量 | 381.39 |
分子式 | C22H15N5O2 |
CAS No. | 2411174-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
VEGFR-2-IN-23 2411174-53-1 Inhibitor inhibitor inhibit