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FGIN-1-27

Name: FGIN-1-27
Brand: TargetMol
SKU: T22782
Price: 111 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T22782Cas号 142720-24-9

FGIN 1-27 是一种吲哚乙酰胺，是外周苯二氮卓受体的特异性的配体，Ki 为 5.0 nM。FGIN 1-27 可以透过血脑屏障。FGIN 1-27对异烟肼引起的抽搐发作具有抑制作用。

为众多的药物研发团队赋能，

让新药发现更简单！

FGIN-1-27

一键复制产品信息

很棒

纯度: 99.86%

货号 T22782Cas号 142720-24-9

规格	价格	库存
1 mg	¥ 111	现货
5 mg	¥ 238	现货
10 mg	¥ 391	现货
25 mg	¥ 792	现货
50 mg	¥ 1,180	现货
100 mg	¥ 1,990	现货
200 mg	¥ 2,880	现货
1 mL x 10 mM (in DMSO)	¥ 273	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.86%

颜色: 白色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

FGIN-1-27 AI Summary

FGIN-1-27 exhibits a wide range of bioactivities across multiple targets and cell types. It demonstrates high binding affinity to the mitochondrial DBI receptor complex (TSPO) in glial cells with a Ki value of 4.4 nM and displaces [3H]PK11195 binding from the peripheral benzodiazepine receptor in C6 rat glioma and MA-10 mouse Leydig cells, with an IC50 of 10.0 nM. Additionally, it binds to human PBR with a Kd of 4.0 nM and shows antineophobic and anti-anxiety activities in rats, indicated by increased entries and time spent in the open arms of an elevated maze test. It enhances pregnenolone formation in the mitochondria of C6-2B glioma cells with an EC50 of 3.0 nM. Additionally, FGIN-1-27 demonstrates antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 3162.28 nM to 10000.0 nM. The compound also exhibits antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 73.55% at 10 µM after 48 hours and showing limited inhibition against SARS-CoV-2 3CL-Pro protease and cytotoxicity in VERO-6 cells. It has shown potential HDAC6 inhibitory activity, although this finding requires further investigation. Overall, FGIN-1-27 displays a diverse array of bioactivities across neuroprotective, antimalarial, and antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM). FGIN 1-27 can cross the blood-brain barrier.
靶点活性	PBR:5.0 nM(Ki)

化学信息

分子量	436.6
分子式	C₂₈H₃₇FN₂O
CAS No.	142720-24-9
Smiles	CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
密度	1.0538 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 4.37 mg/mL (10.01 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.29 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2904 mL	11.4521 mL	22.9043 mL	114.5213 mL
5 mM	0.4581 mL	2.2904 mL	4.5809 mL	22.9043 mL
10 mM	0.2290 mL	1.1452 mL	2.2904 mL	11.4521 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。