购物车

您的购物车当前为空

Tizanidine hydrochloride

Name: Tizanidine hydrochloride
Brand: TargetMol
SKU: T0290
Price: 191 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.96%

货号 T0290Cas号 64461-82-1

别名 盐酸替扎尼定, Tizanidine HCl, DS 103-282

Tizanidine hydrochloride (Tizanidine HCl) 是一种 α2-肾上腺素受体激动剂，可抑制神经递质从 CNS 去甲肾上腺素激活的神经元中释放。

Tizanidine hydrochloride

一键复制产品信息

很棒

纯度: 99.96%

货号 T0290 别名 盐酸替扎尼定, Tizanidine HCl, DS 103-282Cas号 64461-82-1

Tizanidine hydrochloride (Tizanidine HCl) 是一种 α2-肾上腺素受体激动剂，可抑制神经递质从 CNS 去甲肾上腺素激活的神经元中释放。

规格	价格	库存
10 mg	¥ 288	现货
25 mg	¥ 457	现货
50 mg	¥ 672	现货
100 mg	¥ 913	现货
200 mg	¥ 1,350	现货
500 mg	¥ 2,280	现货
1 mL x 10 mM (in DMSO)	¥ 191	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.96%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Tizanidine hydrochloride AI Summary

Tizanidine hydrochloride is a multifaceted bioactive agent displaying diverse pharmacological effects across various biological targets. It acts as an inhibitor of several enzymes, with notable potencies: AmpC Beta-Lactamase (5623.4 nM), BAZ2B (707.9 nM), delayed death in the malarial parasite plastid (11689.1 nM), and Polymerase Iota (31622.8 nM). Additionally, Tizanidine hydrochloride induces DNA re-replication in MCF 10a normal breast cells (4.1 nM) and SW480 colon adenocarcinoma cells (259.3 nM). The compound’s antiviral activity against SARS-CoV-2 is limited, showing minimal inhibition effects on viral-induced cytotoxicity in various cell lines, including Caco-2 and VERO-6 cells, with slight inhibition percentages at 10-20 μM concentrations. It exhibits low efficacy in SARS-CoV-2 3CL-Pro protease inhibition and an overall lack of positive impact on cell viability against SARS-CoV-2. In terms of antimicrobial properties, Tizanidine hydrochloride exhibits mild antibacterial activity, inhibiting the growth of Escherichia coli (6.6%), Klebsiella pneumoniae (10.36%), Pseudomonas aeruginosa (18.39%), and Acinetobacter baumannii (4.87%), while showing negligible or negative effects on Candida albicans, Cryptococcus neoformans, and Staphylococcus aureus MRSA. The compound's effects on cell viability are cell type-dependent, influencing growth rates in assays involving U2OS, human fibroblasts, and HEK293T cells variably. It also affects the thermal stability of different protein domains, suggesting a modulatory effect on protein conformation and stability, with observed changes ranging from -1.91°C to +1.21°C. Furthermore, Tizanidine hydrochloride demonstrates diverse interactions with GPCR targets, affecting beta-arrestin recruitment. It inhibits receptors such as GPR119, GLP1R, and FPR2 while activating others like ADRA2A and AGTR1, indicating its broad and variable receptor modulatory capabilities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.
别名	盐酸替扎尼定, Tizanidine HCl, DS 103-282

化学信息

分子量	290.17
分子式	C₉H₉Cl₂N₅S
CAS No.	64461-82-1
Smiles	Cl.Clc1c(NC2=NCCN2)c2nsnc2cc1
密度	no data available

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (155.08 mM), Sonication is recommended.

H2O: 29 mg/mL (99.94 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.23 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4463 mL	17.2313 mL	34.4626 mL	172.3128 mL
5 mM	0.6893 mL	3.4463 mL	6.8925 mL	34.4626 mL
10 mM	0.3446 mL	1.7231 mL	3.4463 mL	17.2313 mL
20 mM	0.1723 mL	0.8616 mL	1.7231 mL	8.6156 mL
50 mM	0.0689 mL	0.3446 mL	0.6893 mL	3.4463 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0345 mL	0.1723 mL	0.3446 mL	1.7231 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

α2 adrenergic receptor Tizanidine hydrochloride Tizanidine Inhibitor inhibit Beta Receptor AdrenergicReceptor Adrenergic Receptor

Tizanidine hydrochloride

Tizanidine hydrochloride