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Thonzonium Bromide

Name: Thonzonium Bromide
Brand: TargetMol
SKU: T2188
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 通佐溴胺, 嘧苯十六铵

货号 T2188Cas号 553-08-2 一键复制产品信息纯度: 99.94%

很棒

Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。

Thonzonium Bromide

一键复制产品信息

很棒

纯度: 99.94%

货号 T2188Cas号 553-08-2

别名 通佐溴胺, 嘧苯十六铵

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 413	现货
25 mg	¥ 886	现货
50 mg	¥ 1,650	现货
100 mg	¥ 2,890	现货
500 mg	¥ 6,590	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.48%

颜色: 白色

资源下载: COA HPLC LCMS HNMR产品操作手册

产品介绍

Thonzonium Bromide AI Summary

Thonzonium Bromide demonstrates bioactivity across multiple biological pathways and exhibits inhibition of various viral, bacterial, and fungal targets. It shows significant potency in inhibiting proteins such as ubiquitin-specific protease USP2a, mitochondrial division and fusion regulators, lipid storage modulators, and enzymes like AmpC Beta-Lactamase. It is effective in modulating glucocerebrosidase activity for Gaucher Disease treatment and shows high inhibition activity on proteins such as Nrf2, TDP1, FEN1, and Beta Cell apoptosis. Thonzonium Bromide binds competitively to the human pregnane X receptor (PXR), activating it in human liver cells and inducing CYP3A4 enzyme expression with a 36.0% induction at an EC50 value of 11200.0 nM. It exhibits antibiofilm activity against Candida albicans with an IC50 value of 13000.0 nM, and antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells, with significant inhibition rates. The compound shows high efficacy against bacterial strains, demonstrating cytotoxicity against Salmonella Typhimurium and Salmonella typhi, and strong inhibition against Escherichia coli GroEL and GroES proteins, leading to a reduction in the refolding of denatured rhodanese and soluble pig heart MDH enzymes, with inhibition rates of 98.0% and 100.0%, respectively. Additionally, Thonzonium Bromide exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease and demonstrates activity against Mycobacterium tuberculosis H37Rv..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo.
别名	通佐溴胺, 嘧苯十六铵

化学信息

分子量	591.71
分子式	C₃₂H₅₅BrN₄O
CAS No.	553-08-2
Smiles	[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1
密度	no data available

储存&溶解度

存储

Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 260 mg/mL (439.4 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6900 mL	8.4501 mL	16.9002 mL	84.5009 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL	16.9002 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL	8.4501 mL
20 mM	0.0845 mL	0.4225 mL	0.8450 mL	4.2250 mL
50 mM	0.0338 mL	0.1690 mL	0.3380 mL	1.6900 mL
100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.8450 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。