规格

价格

库存

数量

10 mg

¥ 137

现货

25 mg

¥ 198

现货

50 mg

¥ 289

现货

100 mg

¥ 413

现货

500 mg

¥ 795

现货

1 g

¥ 1,170

现货

1 mL x 10 mM (in DMSO)

¥ 385

现货

生物活性

产品描述	Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.
靶点活性	α4β2 nAChR:49 nM, α7 nAChR:122 nM
体外活性	在人咽鳞癌细胞中,Benzethonium chloride（9 μM）12小时后会诱导细胞凋亡,并且激活胱天蛋白酶。Benzethonium（5 μM）增强葡萄糖消耗对细胞溶质Ca(2+)浓度和膜联蛋白结合的影响。
体内活性	携带人咽鳞癌细胞肿瘤SCID小鼠体内, Benzethonium chloride（5 mg/kg）抑制移植瘤的生长。
细胞实验	Cells are seeded in 96-well plates at 5,000 per well in 100 μL of growth medium and allowed to incubate for 24 hours. Benzethonium chloride is then added, as indicated, in a total volume of 5 μL. After 48 hours, MTS assay is done according to the specifications of the manufacturer, with DMSO (0.1%)–treated cells as negative control and cisplatin (166.6 μM)–treated cells as positive control.(Only for Reference)
别名	苄索氯铵, Quatrachlor, Phemeride, Hyamine

化学信息

分子量	448.09
分子式	C₂₇H₄₂ClNO₂
CAS No.	121-54-0
Smiles	[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1
密度	1.1. Temperature:20 °C.

储存&溶解度

存储

溶解度信息

DMSO: 45 mg/mL (100.43 mM), Sonication is recommended.

H2O: 83 mg/mL (185.23 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2317 mL	11.1585 mL	22.3169 mL	111.5847 mL
5 mM	0.4463 mL	2.2317 mL	4.4634 mL	22.3169 mL
10 mM	0.2232 mL	1.1158 mL	2.2317 mL	11.1585 mL
20 mM	0.1116 mL	0.5579 mL	1.1158 mL	5.5792 mL
50 mM	0.0446 mL	0.2232 mL	0.4463 mL	2.2317 mL
100 mM	0.0223 mL	0.1116 mL	0.2232 mL	1.1158 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Benzethonium chloride

Benzethonium chloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Benzethonium chloride

Benzethonium chloride