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Bupranolol

Name: Bupranolol
Brand: TargetMol
SKU: T8580
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.63%

货号 T8580Cas号 14556-46-8

别名 布拉洛尔

Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。

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Bupranolol

一键复制产品信息

很棒

纯度: 97.63%

货号 T8580 别名 布拉洛尔Cas号 14556-46-8

Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。

规格	价格	库存
1 mg	¥ 163	现货
5 mg	¥ 372	现货
10 mg	¥ 596	现货
25 mg	¥ 959	现货
50 mg	¥ 1,330	现货
100 mg	¥ 1,990	现货
200 mg	¥ 2,970	现货
1 mL x 10 mM (in DMSO)	¥ 369	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 97.63%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Bupranolol AI Summary

Bupranolol exhibits beta-blocking activity with an activity level of 5.61. It shows potential antiviral efficacy, including significant activity against the Ebola virus, with AC50 values ranging from 5011.9 nM to 28183.8 nM in various assays. Additionally, compound 100929 demonstrates antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity of Caco-2 cells by 43.82% at 10 µM after 48 hours and exhibiting moderate inhibition of viral replication in HRCE cells with a hit score of 0.4669. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 12.15% at a 20 µM concentration and shows minimal inhibition of viral cytotoxicity in VERO-6 cells at 10 µM. Furthermore, compound 100929 inhibits human HDAC6 enzyme activity, with inhibition rates of 14.84% and 7.02% with commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bupranolol is an antagonist of β2-adrenergic receptor and has been used for angina pectoris, hypertension, glaucoma, cardiac arrhythmia and as an antithrombotic.
别名	布拉洛尔

化学信息

分子量	271.78
分子式	C₁₄H₂₂ClNO₂
CAS No.	14556-46-8
Smiles	Cc1ccc(Cl)c(OCC(O)CNC(C)(C)C)c1
密度	1.098g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (91.99 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6794 mL	18.3972 mL	36.7945 mL	183.9723 mL
5 mM	0.7359 mL	3.6794 mL	7.3589 mL	36.7945 mL
10 mM	0.3679 mL	1.8397 mL	3.6794 mL	18.3972 mL
20 mM	0.1840 mL	0.9199 mL	1.8397 mL	9.1986 mL
50 mM	0.0736 mL	0.3679 mL	0.7359 mL	3.6794 mL