Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. Additionally, hCAI/II-IN-4 exhibits anti-hypoxia properties while maintaining low toxicity. This compound is suitable for investigating acute mountain sickness (AMS) in research studies [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. Additionally, hCAI/II-IN-4 exhibits anti-hypoxia properties while maintaining low toxicity. This compound is suitable for investigating acute mountain sickness (AMS) in research studies [1]. |
体外活性 | hCAI/II-IN-4 (compound 6d) (5-200μM; 48 hours) has no apparent cytotoxicity in HEK293 cells [1]. Cell Cytotoxicity Assay [1] Cell Line: HEK293 cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: The cell viability rate was higher than 60%. |
体内活性 | hCAI/II-IN-4 (compound 6d) (400-2000 mg/kg; p.o.; Male BLAB/c mice of hypoxia) has no apparent toxic effect in vivo [1]. Animal Model: Male BLAB/c mice of hypoxia [1] Dosage: 400, 500 and 2000 mg/kg Administration: Oral administration Result: Prolonged the survival time of mice by 29.3% compared with that of the blank control group. |
分子量 | 381.43 |
分子式 | C15H15N3O5S2 |
CAS No. | 2480284-01-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
hCAI/II-IN-4 2480284-01-1 Inhibitor inhibitor inhibit