Sapropterin dihydrochloride

Name: Sapropterin dihydrochloride
Brand: TargetMol
SKU: T7117
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.88%

货号 T7117Cas号 69056-38-8

别名 盐酸沙丙蝶呤, Sapropterin Hydrochloride, 6R-Tetrahydro-L-biopterin dihydrochloride, 6R-BH4 dihydrochloride, (6R)-5,6,7,8-四氢生物蝶呤二盐酸盐

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。

Sapropterin dihydrochloride

一键复制产品信息

很棒

纯度: 99.88%

货号 T7117 别名 盐酸沙丙蝶呤, Sapropterin Hydrochloride, 6R-Tetrahydro-L-biopterin dihydrochloride, 6R-BH4 dihydrochloride, (6R)-5,6,7,8-四氢生物蝶呤二盐酸盐Cas号 69056-38-8

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 417	现货
50 mg	¥ 798	现货
100 mg	¥ 1,398	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.88%

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Sapropterin dihydrochloride AI Summary

Sapropterin dihydrochloride exhibits antiviral properties against SARS-CoV-2 through multiple mechanisms. It inhibits cell viability in Vero E6 cells infected with the virus, demonstrating an inhibition index of 0.4022. Additionally, it reduces SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours, achieving an inhibition rate of 14.33%. Furthermore, Sapropterin dihydrochloride shows inhibitory effects on the SARS-CoV-2 3CL-Pro protease, with an inhibition rate of 4.289% at 20 µM, as determined by a FRET-based assay. However, conflicting data shows a minor inhibition rate of -0.07% in VERO-6 cells, suggesting variability in its antiviral efficacy across different assays and cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
别名	盐酸沙丙蝶呤, Sapropterin Hydrochloride, 6R-Tetrahydro-L-biopterin dihydrochloride, 6R-BH4 dihydrochloride, (6R)-5,6,7,8-四氢生物蝶呤二盐酸盐

化学信息

分子量	314.17
分子式	C₉H₁₇Cl₂N₅O₃
CAS No.	69056-38-8
Smiles	Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNc2[nH]c(N)nc(=O)c2N1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 123.75 mg/mL (393.9 mM), Sonication is recommended.

H2O: 260 mg/mL (827.58 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1830 mL	15.9150 mL	31.8299 mL	159.1495 mL
5 mM	0.6366 mL	3.1830 mL	6.3660 mL	31.8299 mL
10 mM	0.3183 mL	1.5915 mL	3.1830 mL	15.9150 mL
20 mM	0.1591 mL	0.7957 mL	1.5915 mL	7.9575 mL
50 mM	0.0637 mL	0.3183 mL	0.6366 mL	3.1830 mL
100 mM	0.0318 mL	0.1591 mL	0.3183 mL	1.5915 mL