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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Naphazoline

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纯度: 99.79%

货号 T21445Cas号 835-31-4

别名 萘甲唑林, Naphcon-a, Clear Eyes, All Clear, AK-Con

Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。 萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。

Naphazoline
其他形式的 “Naphazoline”:
Naphazoline hydrochloride
Naphazoline hydrochloride (Standard)
Naphazoline nitrate

Naphazoline

一键复制产品信息
Rating icon 很棒

纯度: 99.79%

货号 T21445 别名 萘甲唑林, Naphcon-a, Clear Eyes, All Clear, AK-ConCas号 835-31-4

Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。 萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。

规格价格库存数量
1 mg
¥ 116
现货
5 mg
¥ 235
现货
10 mg
¥ 328
现货
25 mg
¥ 548
现货
50 mg
¥ 793
现货
100 mg
¥ 1,190
现货
200 mg
¥ 1,790
现货
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产品介绍

Naphazoline AI Summary
Naphazoline demonstrates a complex pharmacological profile with both hypotensive and hypertensive activities. In normotensive rats, it causes a 25% decrease in arterial pressure after intravenous administration due to hypotensive effects, while in pithed rats, it leads to an increase in arterial pressure. The compound exhibits significant binding affinities for alpha-1 adrenergic receptors (alpha-1A, alpha-1B, and alpha-1D) and alpha-2 adrenergic receptors, with notable EC50 and Ki values. Specifically, Naphazoline acts as a potent agonist for the human alpha-1A adrenoceptor (EC50 of 63.1 nM) and demonstrates efficacy in alpha-1 receptor subtypes with EC50 values below 5011.87 nM. It also exhibits antagonistic properties against the alpha-2 adrenergic receptor in rat brain membranes (Ki of 5.7 nM). The compound shows binding affinity to various adrenergic receptors, including a high binding affinity to the I2 and I1 imidazoline binding sites. Its partition coefficient at pH 7.4 is -0.52, indicating its distribution between octanol and buffer. Bioactivity studies reveal that Naphazoline has several additional effects, including modulation of lamin A splicing, inhibition of tau fibril formation, ERK signaling pathways, and activity in Cytochrome P450 2D6 assays. Despite these activities, it has shown no hepatic side effects, based on the Drug Induced Liver Injury Prediction System (DILIps). Further antiviral research indicates that Naphazoline inhibits the SARS-CoV-2 3CL-Pro protease and demonstrates antiviral activity against the SARS-CoV-2 virus in VERO-6 cells. However, the potency of its antiviral effects is relatively low (IC50 values > 20000.0 nM). In addition, the compound demonstrates inhibitory activity against human HDAC6 and interacts with various other human receptors, exhibiting both antagonist and agonist activities. The compound's pKa value of 10.3 indicates a strong basic character, influencing its bioactivity in pH-dependent processes. Overall, Naphazoline holds potential for diverse pharmacological applications due to its multifaceted bioactivities, particularly in modulating adrenergic signaling pathways and exhibiting antiviral properties..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.
别名萘甲唑林, Naphcon-a, Clear Eyes, All Clear, AK-Con
化学信息
分子量210.27
分子式C14H14N2
CAS No.835-31-4
SmilesC(C1=NCCN1)C1=CC=CC2=CC=CC=C12
密度1.1063 g/cm3 (Estimated)
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 50 mg/mL (237.79 mM), Sonication is recommended.
H2O: Insoluble
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM4.7558 mL23.7790 mL47.5579 mL237.7895 mL
5 mM0.9512 mL4.7558 mL9.5116 mL47.5579 mL
10 mM0.4756 mL2.3779 mL4.7558 mL23.7790 mL
20 mM0.2378 mL1.1889 mL2.3779 mL11.8895 mL
50 mM0.0951 mL0.4756 mL0.9512 mL4.7558 mL
100 mM0.0476 mL0.2378 mL0.4756 mL2.3779 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

α-adrenergic receptorVEGFRvasoconstrictionvascular hyperpermeabilityVascular endothelial growth factor receptorTumor Necrosis Factor ReceptorTNFRTNF ReceptorNaphthazolineNaphazolineInterleukin RelatedInhibitorinhibitinflammationdecongestivecytokinesconjunctivitisBeta ReceptorAdrenergicReceptorAdrenergic Receptor
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