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顶部相关产品产品介绍化学信息储存和溶解信息计算器

1-Methylhistamine dihydrochloride

Synonyms: 1-甲基组胺二对甲苯磺酸盐
货号 T8790Cas号 6481-48-7 一键复制产品信息纯度: 99.31%
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1-Methylhistamine dihydrochloride 是组胺代谢物。

1-Methylhistamine dihydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.31%

货号 T8790Cas号 6481-48-7

别名 1-甲基组胺二对甲苯磺酸盐

1-Methylhistamine dihydrochloride 是组胺代谢物。

1-Methylhistamine dihydrochloride
其他形式的 “1-Methylhistamine dihydrochloride”:
1-MethylhistamineT13487501-75-7
现货
规格价格库存数量
5 mg
¥ 323
现货
10 mg
¥ 497
现货
25 mg
¥ 996
现货
50 mg
¥ 1,760
现货
100 mg
¥ 2,720
现货
1 mL x 10 mM (in DMSO)
¥ 315
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实验操作小课堂
常见问题解答
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纯度: 99.31%
颜色: 黑色
性状: Solid
资源下载: COA LCMS HPLC HNMR产品操作手册

产品介绍

1-Methylhistamine dihydrochloride AI Summary
1-Methylhistamine dihydrochloride is a potent and multi-target inhibitor with a broad range of bioactivities. It inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 7.1 nM, Histone Lysine Methyltransferase G9a with a potency of 22.4 nM, and shows significant inhibitory activity against other targets including JMJD2A-Tudor Domain, Polymerase Iota, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and receptors involved in Marburg Virus entry into cells. The compound induces DNA re-replication in MCF 10a normal breast cells (10.3 nM) and SW480 colon adenocarcinoma cells (794.3 nM). Additionally, it is an inhibitor in the antimalarial drug lead development for AMA1-RON. 1-Methylhistamine dihydrochloride exhibits in vivo agonist activity at the histamine H2 receptor in anesthetized rats, stimulating gastric acid secretion relative to histamine, and demonstrates low activity levels at the histamine H1 receptor in guinea pig ileum, inducing a contractile response. Its thin-layer chromatography analysis shows retardation factors (Rf) of 0.56 with the MeOH-NH4OH-H2O solvent system and 0.52 with the EtOCH2CH2OH-HCl(11N)-H2O solvent system..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.
别名
1-甲基组胺二对甲苯磺酸盐
化学信息
分子量198.09
分子式C6H13Cl2N3
CAS No.6481-48-7
SmilesCl.Cl.CN1C=NC(CCN)=C1
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 12 mg/mL (60.58 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM5.0482 mL25.2411 mL50.4821 mL252.4105 mL
5 mM1.0096 mL5.0482 mL10.0964 mL50.4821 mL
10 mM0.5048 mL2.5241 mL5.0482 mL25.2411 mL
20 mM0.2524 mL1.2621 mL2.5241 mL12.6205 mL
50 mM0.1010 mL0.5048 mL1.0096 mL5.0482 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

InhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolite1-Methylhistamine Dihydrochloride1Methylhistamine dihydrochloride1-Methylhistamine1 Methylhistamine dihydrochloride
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