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Isoxsuprine hydrochloride

Name: Isoxsuprine hydrochloride
Brand: TargetMol
SKU: T0324
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.38%

货号 T0324Cas号 579-56-6

别名 盐酸异克舒令, 盐酸苯氧丙酚胺, Isolait, Duvadilan

Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂，对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。

Isoxsuprine hydrochloride

一键复制产品信息

很棒

纯度: 99.38%

货号 T0324 别名 盐酸异克舒令, 盐酸苯氧丙酚胺, Isolait, DuvadilanCas号 579-56-6

Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂，对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。

规格	价格	库存
50 mg	¥ 127	现货
100 mg	¥ 176	现货
500 mg	¥ 395	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.38%

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资源下载:

COA LCMS HPLC HNMR 产品操作手册

产品介绍

Isoxsuprine hydrochloride AI Summary

Isoxsuprine hydrochloride exhibits a diverse range of bioactivities. It demonstrates significant uterine relaxant activity by inhibiting oxytocin-induced contractions in isolated rat uterus preparations with an IC50 of 9150.0 nM and also delays the onset of labor in rats at a 10 mg dosage. The compound affects cAMP release and heart rate in rats at varying dosages. In terms of signaling pathways, Isoxsuprine hydrochloride acts as both an agonist and antagonist for the Hypoxia Response Element Signaling Pathway at 125.9 nM, inhibits the ERK signaling pathway at 39810.7 nM, and targets T. brucei phosphofructokinase at 952.8 nM. Additionally, it shows inhibitory effects on HP1-beta Chromodomain interactions, the malarial parasite plastid, DNA re-replication in SW480 colon adenocarcinoma cells, alpha-syn, and Ebola Virus entry. For antiviral activity, the compound exhibits limited inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 (-0.02068%) but shows 16.99% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with 31.28% efficacy at 20 µM. Isoxsuprine hydrochloride also inhibits sodium fluorescein uptake in OATP1B1-transfected (38.44% at 10 µM) and OATP1B3-transfected CHO cells (77.52% at 10 µM). Its antimicrobial activities are modest, with varying inhibition percentages against Candida albicans, Cryptococcus neoformans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA. Finally, it exhibits inhibitory activity against human HDAC6 in an enzymatic assay with significant variance depending on the substrate, showing -62.97% inhibition with a commercial peptide substrate but only 0.83% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
靶点活性	β-adrenoceptor (myometrial):13.65 μΜ (Ki), β-adrenoceptor (placcntal):3.48 μΜ (Ki)
别名	盐酸异克舒令, 盐酸苯氧丙酚胺, Isolait, Duvadilan

化学信息

分子量	337.84
分子式	C₁₈H₂₄ClNO₃
CAS No.	579-56-6
Smiles	Cl.CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1
密度	1.146g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 11.8 mM, Sonication is recommended.

DMSO: 45 mg/mL (133.2 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.77 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9600 mL	14.7999 mL	29.5998 mL	147.9991 mL
5 mM	0.5920 mL	2.9600 mL	5.9200 mL	29.5998 mL
10 mM	0.2960 mL	1.4800 mL	2.9600 mL	14.7999 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1480 mL	0.7400 mL	1.4800 mL	7.4000 mL
50 mM	0.0592 mL	0.2960 mL	0.5920 mL	2.9600 mL
100 mM	0.0296 mL	0.1480 mL	0.2960 mL	1.4800 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

β-adrenergic receptor Isoxsuprine Hydrochloride Isoxsuprine Ionotropic glutamate receptors Inhibitor inhibit iGluR Beta Receptor AdrenergicReceptor Adrenergic Receptor

Isoxsuprine hydrochloride

Isoxsuprine hydrochloride