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Misonidazole

Name: Misonidazole
Brand: TargetMol
SKU: T21899
Price: 263 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.38%

货号 T21899Cas号 13551-87-6

别名 米索硝唑, SR-1354, SR1354, Ro 7-0582

Misonidazole 是一种缺氧肿瘤细胞放射增敏剂，具有抗菌活性。

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Misonidazole

一键复制产品信息

很棒

纯度: 99.38%

货号 T21899 别名 米索硝唑, SR-1354, SR1354, Ro 7-0582Cas号 13551-87-6

Misonidazole 是一种缺氧肿瘤细胞放射增敏剂，具有抗菌活性。

规格	价格	库存
1 mg	¥ 263	现货
2 mg	¥ 378	现货
5 mg	¥ 643	现货
10 mg	¥ 953	现货
25 mg	¥ 1,620	现货
50 mg	¥ 2,430	现货
100 mg	¥ 3,670	现货
200 mg	¥ 5,250	待询
1 mL x 10 mM (in DMSO)	¥ 623	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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选择批次:

纯度: 99.38%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Misonidazole AI Summary

Misonidazole is a multifaceted agent exhibiting various bioactivities. It has a partition coefficient (LogP) of -0.37, indicating low lipophilicity, and shows very low capillary permeability in rat brain (Pc = 0.00001 cm s-1). The compound demonstrates significant cytotoxicity with an IC50 of 12.1 µM against aerobic AA8 cells and exhibits enhanced sensitivity to hypoxic conditions, as indicated by a CT10 value of 8.3 mM-hr and a ratio of aerobic to hypoxic CT10 of 25.0. It also enhances radiation sensitivity in AA8 cells, with a sensitization enhancement ratio (SER) of 1.6 at a concentration of 0.3 mM under hypoxia. Additionally, Misonidazole shows moderate cytotoxic activity in other cell lines, including a hypersensitivity factor of 1.4 against UV4 cells, 3.6 against EMT6 cells, and 1.9 against FME cells. It has a maximum tolerated dose of 5.0 µM/kg in mice and exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in cells. The compound also demonstrates inhibitory effects in enzymatic assays of human HDAC6, with inhibition percentages of around 2.38%. Furthermore, the compound shows antibacterial and antifungal activity against a range of pathogens, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Candida albicans. It shows low chronic aerobic cytotoxicity with a cytotoxicity value of 0.0013 M in Chinese hamster lung fibroblast-like cells and moderate acute toxicity with a value of 0.03 M after 2 hours of exposure. In summary, Misonidazole is characterized by its diverse bioactivities, including cytotoxic, radiosensitizing, antiviral, antibacterial, and enzymatic inhibitory properties. Its low partition coefficient and capillary permeability limit its central nervous system penetration, while its various IC50, CT10, and SER values highlight its potential therapeutic applications under both aerobic and hypoxic conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.
别名	米索硝唑, SR-1354, SR1354, Ro 7-0582

化学信息

分子量	201.18
分子式	C₇H₁₁N₃O₄
CAS No.	13551-87-6
Smiles	N(=O)(=O)C=1N(CC(COC)O)C=CN1
密度	1.3983 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (298.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9707 mL	24.8534 mL	49.7067 mL	248.5337 mL
5 mM	0.9941 mL	4.9707 mL	9.9413 mL	49.7067 mL
10 mM	0.4971 mL	2.4853 mL	4.9707 mL	24.8534 mL
20 mM	0.2485 mL	1.2427 mL	2.4853 mL	12.4267 mL
50 mM	0.0994 mL	0.4971 mL	0.9941 mL	4.9707 mL
100 mM	0.0497 mL	0.2485 mL	0.4971 mL	2.4853 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。