Tacrine

Name: Tacrine
Brand: TargetMol
SKU: T21439
Price: 158 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.97%

货号 T21439Cas号 321-64-2

别名 他克林, Tetrahydroaminocrine, Tacrinum, CS 12602

Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。

Tacrine

一键复制产品信息

很棒

纯度: 99.97%

货号 T21439 别名 他克林, Tetrahydroaminocrine, Tacrinum, CS 12602Cas号 321-64-2

Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。

规格	价格	库存
1 mg	¥ 158	现货
5 mg	¥ 360	现货
10 mg	¥ 523	现货
25 mg	¥ 853	现货
50 mg	¥ 1,300	现货
100 mg	¥ 2,090	现货
200 mg	¥ 3,010	现货
1 mL x 10 mM (in DMSO)	¥ 263	现货

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产品介绍

Tacrine AI Summary

Tacrine exhibits potent inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Its inhibition constants (IC50) are notably low, with values of 23.0 nM and 15.0 nM for electric eel AChE and equine serum BuChE, respectively. The compound demonstrates a higher selectivity for BuChE over AChE, with a selectivity ratio of 0.65. Additionally, Tacrine shows efficacy in reversing scopolamine-induced memory impairment in mice, indicating potential cognitive benefits. Pharmacokinetically, it has an effective permeability, suggesting its ability to cross biological barriers, and it possesses a suitable partition coefficient (logD) favoring appropriate distribution within the body. Moreover, it exhibits moderate hepatotoxicity and has associations with varying levels of cytotoxicity in different cell lines, necessitating careful dosage considerations. These properties position Tacrine as a promising candidate for further exploration in treating conditions related to cholinergic dysfunction, such as Alzheimer's disease..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.
靶点活性	AChE:109 nM
别名	他克林, Tetrahydroaminocrine, Tacrinum, CS 12602

化学信息

分子量	198.26
分子式	C₁₃H₁₄N₂
CAS No.	321-64-2
Smiles	Nc1c2CCCCc2nc2ccccc12
密度	0.9827 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (277.41 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.09 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0439 mL	25.2194 mL	50.4388 mL	252.1941 mL
5 mM	1.0088 mL	5.0439 mL	10.0878 mL	50.4388 mL
10 mM	0.5044 mL	2.5219 mL	5.0439 mL	25.2194 mL
20 mM	0.2522 mL	1.2610 mL	2.5219 mL	12.6097 mL
50 mM	0.1009 mL	0.5044 mL	1.0088 mL	5.0439 mL
100 mM	0.0504 mL	0.2522 mL	0.5044 mL	2.5219 mL