Lisinopril

Name: Lisinopril
Brand: TargetMol
SKU: T21418
Rating: 4.5 (1 reviews)

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纯度: 99.34%

货号 T21418Cas号 76547-98-3

别名 赖诺普利, Zestril, Prinivil, Lisipril, Linopril

Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。

Lisinopril

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纯度: 99.34%

货号 T21418 别名 赖诺普利, Zestril, Prinivil, Lisipril, LinoprilCas号 76547-98-3

Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。

规格	价格	库存
100 mg	¥ 143	5日内发货
200 mg	¥ 215	5日内发货
500 mg	¥ 418	5日内发货

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纯度: 99.34%

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产品介绍

Lisinopril AI Summary

Lisinopril exhibits potent inhibitory activity against the angiotensin-converting enzyme (ACE) with varying IC50 values measured in different assays, prominently including 1.2 nM and 0.1 nM in human serum assays. Its effectiveness in inhibiting ACE suggests potential uses in regulating blood pressure and cardiovascular function. Additionally, Lisinopril displays selectivity towards the ACE C domain over the N domain, with respective Ki values of 51.0 nM and 131.5 nM. Beyond ACE inhibition, this compound has demonstrated antiviral activity against SARS-CoV-2, although with moderate efficacy, and shows specific binding affinities to metal ions such as zinc and cupric. It has been assessed for various pharmacokinetic properties, including a half-life of 42 hours, a volume of distribution at 0.89 L.kg-1, and moderate total clearance and renal clearance each at 1.2 mL.min-1.kg-1. The compound exhibits low oral bioavailability (25.0%) and significant gut-wall elimination escape (Fg = 0.89). Additionally, it is involved in drug-related liver injury with a DILI severity class of 3.0, as evidenced by elevated liver enzyme levels. Lastly, Lisinopril shows inhibitory effects on rabbit and human liver transporters and modest cytotoxicity against human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lisinopril (Prinivil), the angiotensin-converting enzyme (ACE) inhibitor, is used primarily in the treatment of high heart failure, blood pressure, and heart attacks. It is also used for preventing eye and kidney complications in people with diabetes.
别名	赖诺普利, Zestril, Prinivil, Lisipril, Linopril

化学信息

分子量	405.49
分子式	C₂₁H₃₁N₃O₅
CAS No.	76547-98-3
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2
密度	1.251 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 11.1 mg/mL (27.37 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4662 mL	12.3308 mL	24.6615 mL	123.3076 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL	24.6615 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL	12.3308 mL
20 mM	0.1233 mL	0.6165 mL	1.2331 mL	6.1654 mL