购物车

您的购物车当前为空

Lisinopril

Name: Lisinopril
Brand: TargetMol
SKU: T21418
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.34%

货号 T21418Cas号 76547-98-3

别名 赖诺普利, Zestril, Prinivil, Lisipril, Linopril

Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。

Lisinopril

一键复制产品信息

很棒

纯度: 99.34%

货号 T21418 别名 赖诺普利, Zestril, Prinivil, Lisipril, LinoprilCas号 76547-98-3

Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。

规格	价格	库存	数量
50 mg	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.34%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Lisinopril AI Summary

Lisinopril exhibits potent inhibitory activity against the angiotensin-converting enzyme (ACE) with varying IC50 values measured in different assays, prominently including 1.2 nM and 0.1 nM in human serum assays. Its effectiveness in inhibiting ACE suggests potential uses in regulating blood pressure and cardiovascular function. Additionally, Lisinopril displays selectivity towards the ACE C domain over the N domain, with respective Ki values of 51.0 nM and 131.5 nM. Beyond ACE inhibition, this compound has demonstrated antiviral activity against SARS-CoV-2, although with moderate efficacy, and shows specific binding affinities to metal ions such as zinc and cupric. It has been assessed for various pharmacokinetic properties, including a half-life of 42 hours, a volume of distribution at 0.89 L.kg-1, and moderate total clearance and renal clearance each at 1.2 mL.min-1.kg-1. The compound exhibits low oral bioavailability (25.0%) and significant gut-wall elimination escape (Fg = 0.89). Additionally, it is involved in drug-related liver injury with a DILI severity class of 3.0, as evidenced by elevated liver enzyme levels. Lastly, Lisinopril shows inhibitory effects on rabbit and human liver transporters and modest cytotoxicity against human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lisinopril (Prinivil), the angiotensin-converting enzyme (ACE) inhibitor, is used primarily in the treatment of high heart failure, blood pressure, and heart attacks. It is also used for preventing eye and kidney complications in people with diabetes.
别名	赖诺普利, Zestril, Prinivil, Lisipril, Linopril

化学信息

分子量	405.49
分子式	C₂₁H₃₁N₃O₅
CAS No.	76547-98-3
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCCN)(=O)N2[C@H](C(O)=O)CCC2
密度	1.251 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 11.1 mg/mL (27.37 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4662 mL	12.3308 mL	24.6615 mL	123.3076 mL
5 mM	0.4932 mL	2.4662 mL	4.9323 mL	24.6615 mL
10 mM	0.2466 mL	1.2331 mL	2.4662 mL	12.3308 mL
20 mM	0.1233 mL	0.6165 mL	1.2331 mL	6.1654 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

MK-521 MK521 MK 521 Lisinopril Inhibitor inhibit Angiotensin-converting Enzyme (ACE)ACE

Lisinopril

Lisinopril

Lisinopril 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词