购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
顶部产品描述包装和储存文件下载化合物库定制化合物库组成
TargetMol | Compound Library

ReFRAME 相关化合物库现货

ReFRAME Related Library

Rating icon 很棒
产品编号 L9230

2018年Jeff Janes 等人通过数据挖掘和文献查询，构建了ReFRAME 化合物库，在美国国家科学院院刊（PNAS）发表了关于ReFRAME 化合物库的应用和实用性；其中大部分已通过I 期临床研究具有临床安全性，ReFRAME 化合物库临床安全的独特性质将显著缩短候选药物进入临床的时间，降低失败风险，可高效应用于早期药物研发阶段的筛选以及先导化合物的发现。作者分享了ReFRAME 化合物库，旨在促进数据共享和药物发现机会。盖茨基金会和清华大学等创办的全球健康药物研发中心(GHDDI）也将ReFRAME 化合物库应用于抗COVID-19药物研发。 TargetMol 整理了ReFRAME 化合物库包含4080 种化合物，是药物再利用和抗COVID-19药物研发的有效工具。

TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
资源下载
化合物库相关信息
Excel
SDF
联系我们获取更多批次信息

产品编号 L9230

ReFRAME 相关化合物库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
询价 & 定制

产品描述 产品描述

  • 4080化合物的独特集合，可用于高通量筛选和高内涵筛选，是药物再利用和抗COVID-19药物研发的有效工具
  • 部分化合物已上市得到FDA、EMA、NMPA等权威部门审批，大部分已通过I期临床研究;
  • 通过结构多样性聚类分析，具有优良的结构多样性，包含2698个聚类簇（相似程度大于70%的为一簇），平均1.2个化合物一个簇；
  • 涵盖多个研究领域：肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等；
  • 靶点多样，包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等；
  • 详细的说明书，化合物结构、靶点信息、适应症信息、活性描述等；
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

Packaging And Storage | TargetMol 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
  • 干粉蓝冰运输，DMSO溶液干冰运输；
  • 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。

使用TargetMol产品
发表顶级期刊文献

引用更多关于TargetMol产品的科学文献吧！

查看更多

Supporting Files | TargetMol 文件下载

化合物库操作手册 (635 KB) Targetmol化合物库目录 (60.2 MB)

Library Customization | TargetMol 化合物库定制

Compound Library | TargetMol
您可以通过点击按钮
定制您专属的化合物！
联系专属定制

Library Customization | TargetMol 化合物库组成

Autophagy
Apoptosis
Antibacterial
Antibiotic
Endogenous Metabolite
5-HT Receptor
COX
Adrenergic Receptor
Dopamine Receptor
Parasite
AChR
HIV Protease
Antifungal
DNA/RNA Synthesis
Histamine Receptor
Potassium Channel
Calcium Channel
PDE
Sodium Channel
VEGFR
PI3K
GABA Receptor
PPAR
Cytochromes P450
Topoisomerase
Glucocorticoid Receptor
HCV Protease
Dehydrogenase
Estrogen/progestogen Receptor
Prostaglandin Receptor
Reactive Oxygen Species
EGFR
Influenza Virus
Microtubule Associated
FLT
RAAS
SARS-CoV
Adenosine Receptor
NF-κB
Ferroptosis
CDK
JAK
FGFR
PDGFR
Estrogen Receptor/ERR
HDAC
Nucleoside Antimetabolite/Analog
Src
c-Met/HGFR
Mitophagy
mTOR
GPCR
p38 MAPK
MAO
Androgen Receptor
c-Kit
Reverse Transcriptase
iGluR
HBV
TRP/TRPV Channel
HSV
GluR
Virus Protease
Opioid Receptor
TNF
Proteasome
ATPase
Antioxidant
Progesterone Receptor
ROS
Carbonic Anhydrase
Bcr-Abl
NMDAR
Aurora Kinase
HSP
MEK
Tyrosine Kinases
PKC
Raf
Akt
Lipoxygenase
Antiviral
Serotonin Transporter
IL Receptor
Antifection
Cholinesterase (ChE)
Endothelin Receptor
MMP
P-gp
AMPK
Transferase
Integrin
Reductase
Phosphatase
CCR
Norepinephrine
ALK
Beta Amyloid
Retinoid Receptor
STAT
LPL Receptor
DPP-4
Epigenetic Reader Domain
TLR
ribosome
Phospholipase
Cannabinoid Receptor
Histone Methyltransferase
DNA Alkylator/Crosslinker
PARP
Caspase
E1/E2/E3 Enzyme
CXCR
c-RET
Thrombin
HIF/HIF Prolyl-Hydroxylase
S1P Receptor
Monoamine Oxidase
Thyroid hormone receptor(THR)
Proton pump
Gamma-secretase
Drug Metabolite
Mitochondrial Metabolism
SGLT
Acyltransferase
Neurokinin receptor
Cysteine Protease
ERK
DNA Alkylation
TGF-beta/Smad
Bcl-2 Family
Nrf2
Syk
NO Synthase
DHFR
DNA-PK
PKA
Hedgehog/Smoothened
Vasopressin Receptor
Interleukin
Trk receptor
HMG-CoA Reductase
Tyrosinase
GSK-3
MRP
FXR
ROCK
Guanylate cyclase
Xanthine Oxidase
CaMK
Aromatase
Hydroxylase
PLK
Sigma receptor
TAM Receptor
CFTR
p53
Amino Acids and Derivatives
Cholecystokinin Receptor
Wnt/beta-catenin
IGF-1R
RSV
HIF
HER
ADC Cytotoxin
LTR
NADPH
CETP
Glutathione Peroxidase
Serine Protease
Antifolate
Leukotriene Receptor
Smo
OX Receptor
IκB/IKK
ATM/ATR
c-Fms
Ras
FAK
Chloride channel
NOS
Factor Xa
Glucokinase
IAP
FAAH
Chk
Indoleamine 2,3-Dioxygenase (IDO)
Platelet aggregation
Mdm2
P2Y Receptor
JNK
Serine/threonin kinase
P2X Receptor
ABC Transporter
Beta-Secretase
Casein Kinase
Ligand for E3 Ligase
LPA Receptor
BACE
Tie-2
Melatonin Receptor
CaSR
Rho
Aryl Hydrocarbon Receptor
IDO
CSF-1R
Immunology/Inflammation related
Annexin A
MT Receptor
DNA gyrase
Glucosidase
Monoamine Transporter
PAK
PGE Synthase
Aminopeptidase
NOD
S6 Kinase
ROS Kinase
BTK
ROR
IFNAR
UGT
Molecular Glues
Fatty Acid Synthase
DNA
OAT
Sirtuin
Ephrin Receptor
PAI-1
Acetyl-CoA Carboxylase
PDK
GHSR
Adenosine Deaminase
Anti-infection
DNA Methyltransferase
AhR
NOD-like Receptor (NLR)
Imidazoline Receptor
Kinesin
Monocarboxylate transporter
CRM1
Arginase
Na+/Ca2+ Exchanger
GNRH Receptor
Pim
NAMPT
Myosin
IRE1
PAFR
GlyT
Hexokinase
Isocitrate Dehydrogenase (IDH)
HCN Channel
Bradykinin Receptor
Angiotensin-converting Enzyme (ACE)
Epoxide Hydrolase
BCRP
STING
transporter
Decarboxylase
CRFR
Oxytocin Receptor
Gap Junction Protein
Protease-activated Receptor
Vitamin
Advanced Glycation End Products
Adenylyl Cyclase
MicroRNA
DprE1
Ligands for Target Protein for PROTAC
Histone Demethylase
gp120/CD4
c-Myc
Galectin
Liver X Receptor
Glutaminase
FLAP
RIP kinase
LDL
Glucagon Receptor
Phosphorylase
Na-K-Cl cotransporter
Neuropeptide Y Receptor
Stearoyl-CoA Desaturase (SCD)
Somatostatin
KSP
cAMP
Thrombopoietin Receptor
DUB
Telomerase
ATP Citrate Lyase
Wee1
Lipid
MAPK
Glutathione reductase
Porcupine
Free radical scavengers
GPCR19
GluCls
Neprilysin
Melanocortin Receptor
CRISPR/Cas9
CGRP Receptor
SGK
Complement System
Discoidin Domain Receptor (DDR)
NADPH-oxidase
Kras
Melanin-concentrating Hormone Receptor (MCHR)
Taste receptor
PROTACs
GSNOR
NPC1L1
Hydrogenase
RAR/RXR
MALT
NEDD8
YAP
Procollagen C Proteinase
Cell wall
Lipase
PERK
TOPK
VDA
N-Acetylglucosaminyltransferase
VDAC
Hck
Cell Cycle Arrest
Neurotensin Receptor
PYK2
RANKL/RANK
Prolyl Endopeptidase (PREP)
Anion Exchanger
Thioredoxin
ACK1
PAD
Mucin
Survivin
MNK
LRRK2
Histone Acetyltransferase
ASK
Pyroptosis
Methionine Adenosyltransferase (MAT)
Carboxypeptidase
GPX
Protease
PI4K
KLF
IRAK
Lysosomal Autophagy
p97
PD-1/PD-L1
PKM

Keywords

ReFRAMELibrary
TargetMol | Logo

版权所有©2015-2025 TargetMol Chemicals Inc.保留所有权利.

沪ICP备20019793号-4沪公网安备 31010602006700号TargetMol | Copyright