规格

价格

库存

数量

25 mg

¥ 10,600

3-6月

50 mg

¥ 13,800

3-6月

100 mg

¥ 17,500

3-6月

1 mL x 10 mM (in DMSO)

¥ 3,190

3-6月

生物活性

产品描述	QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
靶点活性	KDM4C:35 nM, KDM4B:56 nM, KDM4D:104 nM, KDM5B:750 nM, KDM4A:104 nM
体外活性	QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2].
体内活性	QC6352 strongly affects tumor growth and the final tumor weight of both BCSC1 and BCSC2 xenografts. QC6352 treatment is well tolerated and does not affect body weight of the mice. Treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].

化学信息

分子量	387.47
分子式	C₂₄H₂₅N₃O₂
CAS No.	1851373-36-8
Smiles	CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
密度	1.243 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (64.52 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (3.87 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO