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CX516

Name: CX516
Brand: TargetMol
SKU: T1884
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.90%

货号 T1884Cas号 154235-83-3

别名 安帕来斯, BDP 12, Ampalex, Ampakine CX516

CX516 (Ampalex) 是AMPA 受体正向调节剂，可用于研究阿尔茨海默病，精神分裂等。

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CX516

一键复制产品信息

很棒

纯度: 99.90%

货号 T1884 别名 安帕来斯, BDP 12, Ampalex, Ampakine CX516Cas号 154235-83-3

CX516 (Ampalex) 是AMPA 受体正向调节剂，可用于研究阿尔茨海默病，精神分裂等。

规格	价格	库存
2 mg	¥ 129	现货
5 mg	¥ 198	现货
10 mg	¥ 328	现货
25 mg	¥ 475	现货
50 mg	¥ 591	现货
100 mg	¥ 768	现货
200 mg	¥ 1,370	现货
1 mL x 10 mM (in DMSO)	¥ 227	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: ≥95%

颜色: 白色

性状: Solid

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COA HNMR 产品操作手册

产品介绍

CX516 AI Summary

CX516 is a versatile chemical entity with multiple biological activities across different assays and targets. When tested for potentiation of the human iGluR4 receptor expressed in HEK293 cells, it showed an EC50 value greater than 1,000,000 nM, suggesting insignificant potentiation at the tested concentrations. Despite this, it exhibits inhibitory effects on GluR3/4 in rat hippocampal neurons with an EC50 of 95,000 nM and on GluR4 expressed in HEK293 cells with EC50 values of 156,000 nM and greater than 1,000,000 nM, alongside agonist activity at rat AMPA receptors indicated by a 68% change in EPSC amplitude. Additionally, CX516 demonstrates antiviral activity. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours with an inhibition rate of -8.12%. It also shows moderate inhibitory activity against SARS-CoV-2 3CL-Pro protease at 20 µM, evidenced by inhibition percentages of 27.86% and 18.42% in FRET-based assays. In VERO-6 cells, its inhibition of SARS-CoV-2 induced cytotoxicity varied between -0.08% and 0.02% at 10 µM. The IC50 values for its inhibitory action against virus-induced cytotoxicity in these cells were greater than 20,000 nM and 19,952.62 nM, reflecting a moderate to low potency. Investigations into its inhibitory activity towards human HDAC6 via enzymatic assays using both commercial and custom peptide substrates revealed inhibition rates of -11.59% and -1.26%, respectively. Furthermore, CX516 is a potent inhibitor of the enzyme 15-PGDH, as shown by an IC50 value of 100 nM when using NAD as a substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
别名	安帕来斯, BDP 12, Ampalex, Ampakine CX516

化学信息

分子量	241.29
分子式	C₁₄H₁₅N₃O
CAS No.	154235-83-3
Smiles	O=C(N1CCCCC1)C1=CC2=NC=CN=C2C=C1
密度	1.236 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (207.22 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.29 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1444 mL	20.7220 mL	41.4439 mL	207.2195 mL
5 mM	0.8289 mL	4.1444 mL	8.2888 mL	41.4439 mL
10 mM	0.4144 mL	2.0722 mL	4.1444 mL	20.7220 mL
20 mM	0.2072 mL	1.0361 mL	2.0722 mL	10.3610 mL
50 mM	0.0829 mL	0.4144 mL	0.8289 mL	4.1444 mL
100 mM	0.0414 mL	0.2072 mL	0.4144 mL	2.0722 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。