购物车
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部相关产品产品介绍化学信息储存和溶解信息计算器

Tetracaine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.94%

货号 T1198Cas号 136-47-0

别名 盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride

Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。

Tetracaine hydrochloride
其他形式的 “Tetracaine hydrochloride”:
Tetracaine-d6
Tetracaine Hydrochloride (Standard)

Tetracaine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.94%

货号 T1198 别名 盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochlorideCas号 136-47-0

Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。

规格价格库存数量
500 mg
¥ 164
现货
1 g
¥ 249
现货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
选择批次:
纯度: 99.94%
联系我们 获取更多批次信息
资源下载:
COA HNMR LCMS产品操作手册

产品介绍

生物活性
产品描述
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been used for surface and spinal anesthesia.
别名盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride
化学信息
分子量300.82
分子式C15H25ClN2O2
CAS No.136-47-0
SmilesCl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
密度1.1279 g/cm3 (Estimated)
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: 28 mg/mL (93.08 mM), Sonication is recommended.
H2O: 55 mg/mL (182.83 mM), Sonication is recommended.
DMSO: 40 mg/mL (132.97 mM), Sonication is recommended.
溶液配制表
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM3.3242 mL16.6212 mL33.2425 mL166.2124 mL
5 mM0.6648 mL3.3242 mL6.6485 mL33.2425 mL
10 mM0.3324 mL1.6621 mL3.3242 mL16.6212 mL
20 mM0.1662 mL0.8311 mL1.6621 mL8.3106 mL
50 mM0.0665 mL0.3324 mL0.6648 mL3.3242 mL
DMSO/H2O
1mg5mg10mg50mg
100 mM0.0332 mL0.1662 mL0.3324 mL1.6621 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Tetracaine hydrochloride exhibits a wide range of bioactivities. It demonstrates potency in inhibiting the proliferation of Plasmodium falciparum lines 3D7, GB4, and D10, and modulates various cellular activities such as Lamin A splicing, erasure of genomic imprints, and inducing DNA re-replication. Additionally, it inhibits several enzymes and proteins, including Human Jumonji Domain Containing 2E, Rab9 Promoter, APE1, N370S glucocerebrosidase, BAZ2B, TGF-b, Histone Lysine Methyltransferase G9a, Bloom's syndrome helicase, 15-hLO-2, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It blocks the entry of Marburg and Ebola viruses and displays potencies ranging from nanomolar to micromolar concentrations. The compound has been evaluated using the Drug Induced Liver Injury Prediction System (DILIps) validation dataset and is identified as DILI negative based on Pfizer data. At an equimolar substrate-inhibitor concentration of 10 µM, Tetracaine hydrochloride inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells with an inhibitory activity of 88.3% and 61.91%, respectively. Tetracaine hydrochloride also shows significant antiviral activities. In Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), it exhibits an inhibition index of 0.4749 at an MOI of 0.002 after 72 hours. It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 18.71% at a concentration of 10 µM after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease activity by 29.79% at a concentration of 20 µM as determined through a FRET response. Additionally, it demonstrates inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells by 0.04% at 10 µM after 48 hours exposure..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

voltage-sensitiveTetracaine hydrochlorideTetracaineSodiumChannelSodium ChannelsarcoplasmicreticulumreleaseproteinInhibitorinhibitchannelCalciumChannelCalcium ChannelcalciumCa2+ channelsCa2+Ca channelsAmethocaine HydrochlorideAmethocaine
Related Tags: buy Tetracaine hydrochloride | purchase Tetracaine hydrochloride | Tetracaine hydrochloride cost | order Tetracaine hydrochloride | Tetracaine hydrochloride chemical structure | Tetracaine hydrochloride formula | Tetracaine hydrochloride molecular weight