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Tetracaine hydrochloride

Name: Tetracaine hydrochloride
Brand: TargetMol
SKU: T1198
Price: 164 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.94%

货号 T1198Cas号 136-47-0

别名 盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride

Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。

Tetracaine hydrochloride

一键复制产品信息

很棒

纯度: 99.94%

货号 T1198 别名 盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochlorideCas号 136-47-0

规格	价格	库存	数量
500 mg	¥ 164	现货
1 g	¥ 249	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.94%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Tetracaine hydrochloride AI Summary

Tetracaine hydrochloride exhibits a wide range of bioactivities. It demonstrates potency in inhibiting the proliferation of Plasmodium falciparum lines 3D7, GB4, and D10, and modulates various cellular activities such as Lamin A splicing, erasure of genomic imprints, and inducing DNA re-replication. Additionally, it inhibits several enzymes and proteins, including Human Jumonji Domain Containing 2E, Rab9 Promoter, APE1, N370S glucocerebrosidase, BAZ2B, TGF-b, Histone Lysine Methyltransferase G9a, Bloom's syndrome helicase, 15-hLO-2, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It blocks the entry of Marburg and Ebola viruses and displays potencies ranging from nanomolar to micromolar concentrations. The compound has been evaluated using the Drug Induced Liver Injury Prediction System (DILIps) validation dataset and is identified as DILI negative based on Pfizer data. At an equimolar substrate-inhibitor concentration of 10 µM, Tetracaine hydrochloride inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells with an inhibitory activity of 88.3% and 61.91%, respectively. Tetracaine hydrochloride also shows significant antiviral activities. In Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), it exhibits an inhibition index of 0.4749 at an MOI of 0.002 after 72 hours. It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 18.71% at a concentration of 10 µM after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease activity by 29.79% at a concentration of 20 µM as determined through a FRET response. Additionally, it demonstrates inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells by 0.04% at 10 µM after 48 hours exposure..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been used for surface and spinal anesthesia.
别名	盐酸丁卡因, Tetracaine HCl, Amethocalne HCl, Amethocaine hydrochloride

化学信息

分子量	300.82
分子式	C₁₅H₂₅ClN₂O₂
CAS No.	136-47-0
Smiles	Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
密度	1.1279 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 28 mg/mL (93.08 mM), Sonication is recommended.

H2O: 55 mg/mL (182.83 mM), Sonication is recommended.

DMSO: 40 mg/mL (132.97 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3242 mL	16.6212 mL	33.2425 mL	166.2124 mL
5 mM	0.6648 mL	3.3242 mL	6.6485 mL	33.2425 mL
10 mM	0.3324 mL	1.6621 mL	3.3242 mL	16.6212 mL
20 mM	0.1662 mL	0.8311 mL	1.6621 mL	8.3106 mL
50 mM	0.0665 mL	0.3324 mL	0.6648 mL	3.3242 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
100 mM	0.0332 mL	0.1662 mL	0.3324 mL	1.6621 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Tetracaine hydrochloride

Tetracaine hydrochloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Tetracaine hydrochloride

Tetracaine hydrochloride