Enflurane

Name: Enflurane
Brand: TargetMol
SKU: T19658
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.64%

货号 T19658Cas号 13838-16-9

别名 恩氟烷, NSC-115944, NSC115944, NSC 115944, Ethrane, Efrane

Enflurane (Efrane) 是一种挥发性麻醉剂，是 Chara australis 高电导 Ca2+ 激活的 K+ 通道的有效抑制剂。安氟醚是通过顶空气相色谱-质谱法监测卤化挥发性麻醉剂的内标。它可以快速调整麻醉深度，而脉搏或呼吸频率几乎没有变化。

Enflurane

一键复制产品信息

很棒

纯度: 99.64%

货号 T19658 别名 恩氟烷, NSC-115944, NSC115944, NSC 115944, Ethrane, EfraneCas号 13838-16-9

规格	价格	库存
50 mg	¥ 198	现货
100 mg	¥ 289	现货
500 mg	¥ 679	现货

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产品介绍

Enflurane AI Summary

Enflurane is characterized by its ability to cross the blood-brain barrier, indicated by a brain to blood partition coefficient (logBB) value of 0.24. It has anesthetic properties, with minimum alveolar concentrations (MAC) of 2.06 in dogs and 1.68 in humans, and displays a high oil/gas partition coefficient of 98.0. In terms of distribution within the body, it shows moderate partition coefficients between blood and lung, with logP(lung) = 0.21, logK(blood) = 0.35, and logK(lung) = 0.56. The compound exhibits bioactivities related to hepatic side effects, with a composite HepSE score of 2.0, indicating potential impacts on liver health such as hepatic failure and necrosis. It is also characterized by moderate liver toxicity, including cytolytic and cholestatic liver toxicity, granulomatous hepatitis, and acute liver toxicity. Additionally, Enflurane shows antiviral activity against SARS-CoV-2. It inhibits the virus-induced cytotoxicity in both Caco-2 cells (7.47% inhibition at 10 µM) and Vero-6 cells, though with negligible effect at the latter. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 17.5% at 20 µM. Lastly, it shows inhibitory activity against human HDAC6 with inhibition percentages of -7.61% and -5.78% using different peptide substrates. The compound also shows activity in the Schwann cell PMP22 intronic element firefly luciferase assay, with a potency of 20314.8 nM. Further evaluation is required to fully understand the therapeutic potential and safety profile of Enflurane across these diverse bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry. It allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
别名	恩氟烷, NSC-115944, NSC115944, NSC 115944, Ethrane, Efrane

化学信息

分子量	184.49
分子式	C₃H₂ClF₅O
CAS No.	13838-16-9
Smiles	FC(F)OC(F)(F)C(F)Cl
密度	1.517 g/cm3

储存&溶解度

存储

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (298.12 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4203 mL	27.1017 mL	54.2035 mL	271.0174 mL
5 mM	1.0841 mL	5.4203 mL	10.8407 mL	54.2035 mL
10 mM	0.5420 mL	2.7102 mL	5.4203 mL	27.1017 mL
20 mM	0.2710 mL	1.3551 mL	2.7102 mL	13.5509 mL
50 mM	0.1084 mL	0.5420 mL	1.0841 mL	5.4203 mL
100 mM	0.0542 mL	0.2710 mL	0.5420 mL	2.7102 mL