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Ogerin

Name: Ogerin
Brand: TargetMol
SKU: T16378
Price: 315 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.75%

货号 T16378Cas号 1309198-71-7

Ogerin 是选择性 GPR68正向别构调节剂(pEC50:6.83)。它能够抑制小鼠对恐惧记忆的回忆。它对 A2A 受体具有适中的拮抗作用(Ki:220 nM)。对 5-HT2B 受体的拮抗作用较弱(Ki:736 nM)。

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Ogerin

一键复制产品信息

很棒

纯度: 99.75%

货号 T16378Cas号 1309198-71-7

规格	价格	库存
1 mg	¥ 315	现货
5 mg	¥ 745	现货
10 mg	¥ 1,180	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,790	现货
100 mg	¥ 5,430	现货
1 mL x 10 mM (in DMSO)	¥ 818	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.75%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ogerin AI Summary

Ogerin exhibits a wide range of bioactivities across various cell types and receptor interactions. It has shown varying effects on cell viability, with a growth rate of 1.0 in HEK293T cells, U2OS cells, and some human fibroblast cells, while displaying a growth rate of 0.0 in other instances with HEK293T and human fibroblast cells in Incucyte assays. As a potent allosteric modulator of both mouse and human GPR68, it stimulates proton-mediated cAMP production in HEK293T cells with an activity index ranging from 4.97 to 5.31 and a pKb from 4.13 to 4.35. The compound also affects proton-mediated calcium mobilization in HEK293T cells, with an EC50 of around 148.0 nM in the FLIPR-TETRA assay. Moreover, Ogerin has broad bioactivity, showing inhibitory effects on numerous serotonin, dopamine, adrenergic, opioid, histamine, muscarinic, GABA, and sigma receptors, as well as on serotonin and norepinephrine transporters. Notably, it has an EC50 of 147.91 nM and a Ki ranging from 489.78 to 496.36 nM for the 5-HT2B receptor, indicating significant binding affinity and receptor interaction. Furthermore, Ogerin impacts the thermal stability of protein domains, leading to both positive and negative shifts in melting temperature (TM), suggesting it interacts with multiple sites within proteins, potentially influencing their stability and function..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor.
靶点活性	GPR68:(pEC50)6.83 , A2A receptor:(ki)220 nM, 5-HT2B receptor:(ki)736 nM

化学信息

分子量	307.35
分子式	C₁₇H₁₇N₅O
CAS No.	1309198-71-7
Smiles	Nc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (813.4 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.27 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2536 mL	16.2681 mL	32.5362 mL	162.6810 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL	32.5362 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL	16.2681 mL
20 mM	0.1627 mL	0.8134 mL	1.6268 mL	8.1340 mL
50 mM	0.0651 mL	0.3254 mL	0.6507 mL	3.2536 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6268 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。