NU2058

Name: NU2058
Brand: TargetMol
SKU: T3186
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.92%

货号 T3186Cas号 161058-83-9

别名 O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine

NU2058 (O(6)-Cyclohexylmethylguanine) 是一种基于鸟嘌呤的 CDK 抑制剂，抑制 CDK2 和 CDK1 的IC50值分别为 17 μM 和 26 μM。它也抑制 DNA 拓扑异构酶 II ATPase 活性，具有抗癌活性。

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NU2058

一键复制产品信息

很棒

纯度: 99.92%

货号 T3186 别名 O6-(Cyclohexylmethyl)guanine, O(6)-CyclohexylmethylguanineCas号 161058-83-9

规格	价格	库存
1 mg	¥ 118	现货
5 mg	¥ 239	现货
10 mg	¥ 363	现货
25 mg	¥ 728	现货
50 mg	¥ 1,080	现货
100 mg	¥ 1,650	现货
200 mg	¥ 2,460	现货
1 mL x 10 mM (in DMSO)	¥ 256	现货

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COA HNMR HPLC 产品操作手册

产品介绍

NU2058 AI Summary

NU2058 exhibits a broad range of bioactivities, particularly as an inhibitor of various cyclin-dependent kinases (CDKs) and their respective cyclins. It shows inhibitory effects on Cyclin-dependent kinase 1-cyclin B1 and Cyclin-dependent kinase 2-cyclin A with IC50 values of 7000 nM and 17000 nM, respectively, and Ki values of 5000 nM and 12000 nM, respectively. The compound also demonstrates antiproliferative activity against MCF-7 human breast carcinoma cells with a GI50 value of 20000 nM and an IC50 value of 24200 nM after 3 days. Additionally, NU2058 exhibits antiviral activity against SARS-CoV-2 in VERO-6 cells with an inhibition of cytotoxicity by 51.93% at 10 µM after 48 hours. It shows limited inhibitory effects on AGT activity in HT-29 cell extract with an IC50 value greater than 1,000,000 nM. Moreover, the compound has antimycobacterial activity against Mycobacterium avium and Mycobacterium tuberculosis. Overall, these diverse bioactivities suggest that NU2058 has the potential as a multi-target inhibitor in various biological systems..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
靶点活性	CDK1:26 μM, CDK2:17 μM, CDK2:12 μM (Ki)
别名	O6-(Cyclohexylmethyl)guanine, O(6)-Cyclohexylmethylguanine

化学信息

分子量	247.3
分子式	C₁₂H₁₇N₅O
CAS No.	161058-83-9
Smiles	Nc1nc(OCC2CCCCC2)c2nc[nH]c2n1
密度	1.52 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (242.62 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0437 mL	20.2184 mL	40.4367 mL	202.1836 mL
5 mM	0.8087 mL	4.0437 mL	8.0873 mL	40.4367 mL
10 mM	0.4044 mL	2.0218 mL	4.0437 mL	20.2184 mL
20 mM	0.2022 mL	1.0109 mL	2.0218 mL	10.1092 mL
50 mM	0.0809 mL	0.4044 mL	0.8087 mL	4.0437 mL
100 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0218 mL