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TM2-115

Name: TM2-115
Brand: TargetMol
SKU: T9004
Price: 446 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.67%

货号 T9004Cas号 1197196-47-6

TM2-115 是疟原虫组蛋白甲基转移酶的抑制剂，可导致疟原虫快速且不可逆的死亡。

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TM2-115

一键复制产品信息

很棒

纯度: 97.67%

货号 T9004Cas号 1197196-47-6

TM2-115 是疟原虫组蛋白甲基转移酶的抑制剂，可导致疟原虫快速且不可逆的死亡。

规格	价格	库存
1 mg	¥ 446	现货
5 mg	¥ 1,090	现货
10 mg	¥ 1,780	现货
25 mg	¥ 3,360	现货
50 mg	¥ 4,920	现货
1 mL x 10 mM (in DMSO)	¥ 1,180	现货

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产品介绍

TM2-115 AI Summary

TM2-115 exhibits a broad spectrum of bioactivity with inhibitory effects on diverse targets including human flap endonuclease 1 (FEN1), histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1 (TrxR1), and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It further induces synthetic lethality in tumor cells producing 2HG. The compound shows antimalarial activity, effectively reducing parasitemia in Plasmodium berghei ANKA-infected mice at a dosage of 40 mg/kg. Additionally, it has potent antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 with an IC50 of 43.0 nM and an EC50 of 100.0 nM. Notably, TM2-115 demonstrates poor selectivity for human G9a with an IC50 value greater than 1000.0 nM, and despite its favorable selectivity ratio against Plasmodium falciparum 3D7, it presents cytotoxicity concerns in human HepG2 cells with an IC50 of 4700.0 nM, yielding a selectivity ratio of 110.1..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].

化学信息

分子量	490.64
分子式	C₂₈H₃₈N₆O₂
CAS No.	1197196-47-6
Smiles	N(C=1C2=C(N=C(N1)N3CCN(C)CCC3)C=C(OCC4=CC=CC=C4)C(OC)=C2)C5CCN(C)CC5
密度	1.188 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (91.72 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.08 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0382 mL	10.1908 mL	20.3815 mL	101.9077 mL
5 mM	0.4076 mL	2.0382 mL	4.0763 mL	20.3815 mL
10 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1908 mL
20 mM	0.1019 mL	0.5095 mL	1.0191 mL	5.0954 mL
50 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL