DSP-4 hydrochloride

Name: DSP-4 hydrochloride
Brand: TargetMol
SKU: T13664
Price: 415 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.9%

货号 T13664Cas号 40616-75-9

别名 Neurotoxin DSP 4 (hydrochloride)

DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) 是一种高选择性的神经毒素，主要是来自蓝斑 (LC) 的神经元，容易通过血脑屏障。它对成年和发育中大鼠去甲肾上腺素能神经元具有神经毒性作用，可用于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。

DSP-4 hydrochloride

一键复制产品信息

很棒

纯度: 99.9%

货号 T13664 别名 Neurotoxin DSP 4 (hydrochloride)Cas号 40616-75-9

规格	价格	库存
5 mg	¥ 415	现货
10 mg	¥ 581	现货
50 mg	¥ 1,498	现货
100 mg	¥ 2,318	现货
200 mg	¥ 3,478	现货
1 mL x 10 mM (in DMSO)	¥ 457	现货

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纯度: 99.9%

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COA HNMR LCMS 产品操作手册

产品介绍

DSP-4 hydrochloride AI Summary

DSP-4 hydrochloride exhibits a wide range of bioactivities, including significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 10000.0 nM to 12589.25 nM after 72 hours using the SYBR green assay. It is also potent in inhibiting the proliferation of P. falciparum lines Dd2, 3D7, W2, 7G8, and D10. Additionally, DSP-4 hydrochloride demonstrates capabilities such as inducing genomic imprint erasure, acting as a general anesthetic, modulating Lamin A splicing, and inhibiting cell-membrane permeable IMPase. It is an effective inhibitor of Bloom's syndrome helicase (BLM) and exhibits activity against the Marburg Virus, besides inducing DNA re-replication in various cell types. Moreover, it inhibits norepinephrine reuptake at NET in rat brain cortical synaptosomes with an IC50 of 50.0 nM, and dopamine reuptake at DAT in rat brain striatal synaptosomes with an IC50 of 5870.0 nM, yielding a selectivity ratio of 117.4 for dopamine reuptake to norepinephrine reuptake inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC). is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats,
别名	Neurotoxin DSP 4 (hydrochloride)

化学信息

分子量	313.06
分子式	C₁₁H₁₆BrCl₂N
CAS No.	40616-75-9
Smiles	Cl.CCN(CCCl)Cc1ccccc1Br
密度	1.338g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (399.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.78 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1943 mL	15.9714 mL	31.9428 mL	159.7138 mL
5 mM	0.6389 mL	3.1943 mL	6.3886 mL	31.9428 mL
10 mM	0.3194 mL	1.5971 mL	3.1943 mL	15.9714 mL
20 mM	0.1597 mL	0.7986 mL	1.5971 mL	7.9857 mL
50 mM	0.0639 mL	0.3194 mL	0.6389 mL	3.1943 mL
100 mM	0.0319 mL	0.1597 mL	0.3194 mL	1.5971 mL