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Cariporide

Name: Cariporide
Brand: TargetMol
SKU: T2238
Price: 279 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 卡立泊来德, HOE-642

货号 T2238Cas号 159138-80-4 一键复制产品信息纯度: 99.88%

很棒

Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。

Cariporide

一键复制产品信息

很棒

纯度: 99.88%

货号 T2238Cas号 159138-80-4

别名 卡立泊来德, HOE-642

Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。

规格	价格	库存
2 mg	¥ 279	现货
5 mg	¥ 438	现货
10 mg	¥ 627	现货
25 mg	¥ 1,090	现货
50 mg	¥ 1,630	现货
100 mg	¥ 2,420	现货
500 mg	¥ 5,730	现货
1 mL x 10 mM (in DMSO)	¥ 443	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.88%

颜色: 白色

资源下载: COA HPLC HNMR LCMS产品操作手册

产品介绍

Cariporide AI Summary

Cariporide exhibits diverse bioactivities, primarily targeting the sodium/hydrogen exchanger (NHE) family, with potent inhibition of NHE1 (IC50 of 30.0 nM) and moderate inhibition of NHE2 (IC50 of 4300.0 nM). It shows weak activity against NHE3 and NHE5 (IC50 ≥ 1000.0 nM and >30000.0 nM, respectively). It effectively inhibits NHE1-mediated intracellular pH recovery in various cell types, including rat and human platelets, and acidified rabbit erythrocytes. The compound also demonstrates significant cardioprotective effects, reducing myocardial infarct size and improving heart function in ischemia-reperfusion injury models in rats and guinea pigs. Additionally, it shows efficacy in mitigating serum creatine kinase levels and left ventricular end diastolic pressure during ischemic conditions. Pharmacokinetically, Cariporide has an oral bioavailability of 37.0% in rats, a volume of distribution at steady state of 1.3 L/kg, and a mean residence time of 0.4 hours post-intravenous administration. It exhibits a high clearance rate (82% relative to hepatic blood flow). Further, Cariporide shows modest inhibitory activity against SARS-CoV-2, including its 3CL-Pro protease, with inhibition percentages around 13-14% at 20 µM concentration. Lastly, it demonstrates potential inhibitory effects on human HDAC6, shown by inhibition percentages in enzymatic assays with peptide substrates. Overall, Cariporide holds promise for cardiovascular and antiviral therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cariporide (HOE-642) (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
靶点活性	NHE1:30 nM
别名	卡立泊来德, HOE-642

化学信息

分子量	283.35
分子式	C₁₂H₁₇N₃O₃S
CAS No.	159138-80-4
Smiles	CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)N=C(N)N
密度	1.34g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 250 mg/mL (882.3 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.06 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5292 mL	17.6460 mL	35.2920 mL	176.4602 mL
5 mM	0.7058 mL	3.5292 mL	7.0584 mL	35.2920 mL
10 mM	0.3529 mL	1.7646 mL	3.5292 mL	17.6460 mL
20 mM	0.1765 mL	0.8823 mL	1.7646 mL	8.8230 mL
50 mM	0.0706 mL	0.3529 mL	0.7058 mL	3.5292 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	1.7646 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。