AGI-41998 tautomers

Name: AGI-41998 tautomers
Brand: TargetMol
SKU: T64377
Price: 323 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.79%

货号 T64377

别名 AGI-41998互变异构体

AGI-41998 tautomers 是pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 的互变异构体。pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 是S-adenosylmethionine synthase isoform type-2抑制剂, IC50= 0.022μM。

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AGI-41998 tautomers

一键复制产品信息

很棒

纯度: 99.79%

货号 T64377 别名 AGI-41998互变异构体

规格	价格	库存
1 mg	¥ 323	现货
5 mg	¥ 749	现货
10 mg	¥ 1,090	现货
25 mg	¥ 1,730	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,220	现货
200 mg	¥ 4,330	现货
1 mL x 10 mM (in DMSO)	¥ 826	现货

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产品介绍

AGI-41998 tautomers AI Summary

AGI-41998 tautomers is a potent inhibitor of the MAT2A enzyme, demonstrated by its low IC50 values in inhibiting S-adenosyl methionine production both in recombinant human MAT2A and in MT2A within MTAP-null human HCT-116 cells. It significantly transactivates human PXR in HepG2 cells, leading to CYP450 induction. The compound exhibits moderate permeability across human Caco-2 cells with a low efflux ratio. In vivo studies in mice indicate good bioavailability and tissue distribution, with considerable inhibition of MAT2A enzyme activity in various tissues, including the brain and tumors. Given its high selectivity for reducing SAM production, AGI-41998 tautomers shows promise as a candidate for further research in anti-cancer or metabolic disorder therapies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AGI-41998 tautomers is a tautomerism of pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]- is a S-adenosylmethionine synthase isoform type-2 inhibitor, IC50= 0.022μM.
别名	AGI-41998互变异构体

化学信息

分子量	505.29
分子式	C₂₂H₁₆BrF₃N₄O₂
Smiles	O=C1C(C2=CC=C(Br)C=C2)=C(C(C=N3)=CN1C4=CC=C(OC)C=C4)NC3=NCC(F)(F)F
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (108.85 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9791 mL	9.8953 mL	19.7906 mL	98.9531 mL
5 mM	0.3958 mL	1.9791 mL	3.9581 mL	19.7906 mL
10 mM	0.1979 mL	0.9895 mL	1.9791 mL	9.8953 mL
20 mM	0.0990 mL	0.4948 mL	0.9895 mL	4.9477 mL
50 mM	0.0396 mL	0.1979 mL	0.3958 mL	1.9791 mL
100 mM	0.0198 mL	0.0990 mL	0.1979 mL	0.9895 mL