Acrizanib

Name: Acrizanib
Brand: TargetMol
SKU: T5373
Price: 928 CNY
Availability: InStock
Rating: 5 (10 reviews)

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产品编号 T5373Cas号 1229453-99-9

别名 LHA510

Acrizanib (LHA510) 是一种 VEGFR-2 的抑制剂，其对 BaF3-VEGFR-2 的 IC50 值为 17.4 nM。

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纯度: 99.64%

产品编号 T5373 别名 LHA510Cas号 1229453-99-9

Acrizanib (LHA510) 是一种 VEGFR-2 的抑制剂，其对 BaF3-VEGFR-2 的 IC50 值为 17.4 nM。

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Acrizanib 相关产品

产品介绍

生物活性

产品描述	Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2.
靶点活性	VEGFR2:17.4 nM
体外活性	Acrizanib is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-KDR. Acrizanib exhibits ≤10% remaining kinase activity against only 13 wild type kinases: CSF1R, Kit, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, VEGFR3, Fms (soluble VEGFR1), DDR1, DDR2, TIE1, and ABL1 (nonphosphorylated)[1].
体内活性	Rat ocular PK studies with Acrizanib (compound 35) shows a distinctly different profile from that observed with compound 25. While prolonged exposure is once again evident in the PEC, the AUC ratio to the level of Acrizanib in plasma is markedly increased (>21000-fold higher exposure in the PEC than plasma on day 11). Furthermore, unlike 25, Acrizanib also afford much improved retina to plasma AUC exposure ratio after 10 days of dosing (598× for Acrizanib vs 0.8× for 25)[1].
别名	LHA510

化学信息

分子量	445.4
分子式	C₂₀H₁₈F₃N₇O₂
CAS No.	1229453-99-9
Smiles	CNCc1cc(Oc2ccc3n(ccc3c2)C(=O)Nc2cc(n(C)n2)C(F)(F)F)ncn1
密度	1.47 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 37.8 mg/mL (84.9 mM), Sonication is recommended.

溶液配制表

DMSO